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Re:Heavily mutated coronavirus variant puts scientists on alert by idlewords on Thursday November 25, 2021 @05:41PM (#29345672)
You were on this forum calling covid "a normal seasonal virus" in February of 2020, so maybe sit this one out.
Re:Heavily mutated coronavirus variant puts scientists on alert by argonaut on Thursday November 25, 2021 @06:07PM (#29345870)
Everyone commenting on Covid got something wrong at one point.
Re:Heavily mutated coronavirus variant puts scientists on alert by wheelie_boy on Thursday November 25, 2021 @07:06PM (#29346265)
Everyone has made errors, yes. Ideally we will make fewer in the future.

To that end, we should consider the amount and directionality of errors made by individuals as we consider what weight to give their current predictions.

Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Thursday November 25, 2021 @08:04PM (#29346611)
So when Fauci had this https://www.nejm.org/doi/full/10.1056/NEJMe2002387 published in March 2020 that included the words "This suggests that the overall clinical consequences of Covid-19 may ultimately be more akin to those of a severe seasonal influenza (which has a case fatality rate of approximately 0.1%)", what weighting should we give to his current credibility, would you say?
Re:Heavily mutated coronavirus variant puts scientists on alert by _djo_ on Thursday November 25, 2021 @08:36PM (#29346765)
You’re stripping out important context there. He was comparing it to SARS and MERS with CFRs of 9-10%, so saying COVID-19 would be closer to the influenza end of the spectrum if, and only if, some of the early info on the infection fatality rate was correct.

What you did isn’t a good faith move. There’s tons to criticise Fauci on in any case, you shouldn’t need to selectively quote stuff like this.

Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Thursday November 25, 2021 @08:42PM (#29346795)
I didn't think I was stripping out important context, but I will add more for your:

If one assumes that the number of asymptomatic or minimally symptomatic cases is several times as high as the number of reported cases, the case fatality rate may be considerably less than 1%. This suggests that the overall clinical consequences of Covid-19 may ultimately be more akin to those of a severe seasonal influenza (which has a case fatality rate of approximately 0.1%) or a pandemic influenza (similar to those in 1957 and 1968) rather than a disease similar to SARS or MERS, which have had case fatality rates of 9 to 10% and 36%, respectively.

I don't think that really changes things. The orders of magnitude are 0.1%, 1%, 10%, and he's saying it may be considerably less than 1%, i.e., much closer in relative magnitude (and obviously far nearer in absolute terms) to a seasonal flu.

You are the one who is missing the larger context of this thread, which has been an unfair bullying of someone going back over what they had said 2 years ago about covid and claiming he should "sit this one out". Given this is the position that the experts had back then, clearly having an opinion that it was like a seasonal flu was not way out of line.

And my question to OP about Fauci stands too. Given that is what he wrote, and I provided the link for full context, what credibility should we assign to his current statements.

Re:Heavily mutated coronavirus variant puts scientists on alert by _djo_ on Thursday November 25, 2021 @08:53PM (#29346848)
Again, note the language used. First, it’s a summary of what’s suspected at the time, but with a lot of caveats around what’s uncertain. The statement being made the quoted portion is that it’s likely to have a CFR a lot closer to flu than to MERS or SARS 1. That’s still not inaccurate, what they missed was how infectious it was.

The piece also doesn’t argue against action or vigilance. It highlights the unknowns, risks, and some potential outcomes. As more information came out Fauci and others adjusted their reviews, predictions, and recommendations to suit.

It’s hardly the same thing as the group of people who’ve spent the last two years trying to downplay this virus every chance they got, and refused to learn from getting it wrong. Telling us it wasn’t serious, that it would die out on its own, that we didn’t need interventions like masks and social distancing, and all the rest.

Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Thursday November 25, 2021 @09:22PM (#29346963)
Yep that's what was suspected at the time which is why these experts were saying it's probably more like a seasonal flu than a serious pandemic of other sorts, don't wear a mask, keep traveling, etc. And they were wrong (well, to some extent -- it's still probably around a 1% mortality rate so still arguably closer to a seasonal flu going by Fauci's same reasoning).

Clearly bullying here of a person for pretty much repeating what many experts like Fauci and politicians like Pelosi were saying at the time is way out of line. Hopefully you can agree on that.

Re:Heavily mutated coronavirus variant puts scientists on alert by _djo_ on Friday November 26, 2021 @03:48AM (#29348465)
Experts don't always get it right, but what differentiates those we trust from those we don't is that they're cautious, curious, and learn from new information to adjust their views and recommendations.

Plenty of scientists have admitted that they underestimated aspects of this pandemic, from the effectiveness of masking, to the likelihood and severity of variants, to how quickly vaccines would come on stream. But they learnt from it and moved on.

Someone who downplayed the pandemic from the very beginning and who, in response to a new variant that has virologists and epidemiologists extremely worried, says "this is danger porn. pay it no mind and have happy holidays" is neither a serious person nor worth listening to on this subject. They clearly haven't learnt from their past mistakes, or don't want to.

Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Friday November 26, 2021 @04:50AM (#29348814)
> Experts don't always get it right, but what differentiates those we trust from those we don't is that they're cautious, curious, and learn from new information to adjust their views and recommendations.

I don't think they do necessarily. I have heard very little in the way of contrition or reflection or honest explanation as to why so many got it wrong for so long. Wrong about the virus, wrong about how it spreads, wrong about vaccines, etc. And yet so many of them still act like they are absolutely certain of what they are saying, when it's clear they in fact don't.

Scientists and experts can be egotistical, dogmatic, inflexible, and rusted on to old ideas. That whole Planck's principle thing, you know.

> Someone who downplayed the pandemic from the very beginning and who,

Someone who said what many experts were saying, you mean?

> in response to a new variant that has virologists and epidemiologists extremely worried, says "this is danger porn. pay it no mind and have happy holidays" is neither a serious person nor worth listening to on this subject. They clearly haven't learnt from their past mistakes, or don't want to.

I disagree, I don't see how that follows. The media certainly have certainly hyped things up and exaggerated and peddled this danger porn. The OP was referring to a sentence from a news article, not a quote from a scientist. The claim is not that covid doesn't matter and this variant is harmless, it's that the news article is danger porn.

Which it is. If it's nothing there's not much we can do, if it's bad news there's not much we can do. As other top level comments say, mutations happen all the time. Look how many major variants there are https://www.who.int/en/activities/tracking-SARS-CoV-2-varian... what is there to gain by panicking every time a new one is found?

Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Thursday November 25, 2021 @05:58PM (#29345815)
Weren't "experts" calling for events to continue and that border closures would be racist and that people should not wear masks around that time?

Maybe he was just listening to the experts.

Re:Heavily mutated coronavirus variant puts scientists on alert by dekhn on Thursday November 25, 2021 @07:07PM (#29346268)
Prominent scientists signed their names to articles saying that implying the virus was released from a lab (intentionally or otherwise) was racist and factually wrong.

Those scientists, by and large, have walked back their statements and admit that the hypothesis that this was a lab leak that occurred in Wuhan is not impossible and that stating it is not necessarily racist. Also, those folks aren't considered "experts" any more (everybody else lowered their priors about those expert's beliefs).

Re:Heavily mutated coronavirus variant puts scientists on alert by tcbawo on Thursday November 25, 2021 @06:18PM (#29345950)
I've heard multiple references to experts/politicians/media "calling border closures racist" in early 2020, but only from conservative media claiming that liberals were espousing this viewpoint. Can someone provide sources or evidence for this?
Re:Heavily mutated coronavirus variant puts scientists on alert by post_from_work on Thursday November 25, 2021 @10:01PM (#29347142)
From The Atlantic (https://www.theatlantic.com/politics/archive/2020/02/trump-r...), attributing comments to the WHO:

  *But critics from WHO and elsewhere have said the bans are unnecessary and could generate a racist backlash against Chinese people.*

  *Before long, Trump was running for president on an anti-immigrant platform. One message he pushed was that immigrants carry contagion. In 2015, he put out a statement warning that “tremendous infectious disease is pouring across the border,” a claim unsupported by fact.* [ha! That hasn't aged well: https://news.yahoo.com/dhs-dropped-40-000-covid-190800213.html ]
From Huffington Post: https://www.huffpost.com/archive/in/entry/china-donald-trump...:

  *Just a month after praising China for its handing of the COVID-19 outbreak, U.S. President Donald Trump has sent out a racist tweet terming the coronavirus as “Chinese Virus”.*
From Business Insider: https://www.businessinsider.com/trump-using-racism-against-c...

  *President Donald Trump and his Republican allies are using racism to try to distract from his disastrous preparations for and response to the coronavirus pandemic. Instead of taking responsibility for and addressing early failures, they're blaming the crisis on China.*
Re:Heavily mutated coronavirus variant puts scientists on alert by acwan93 on Thursday November 25, 2021 @07:02PM (#29346241)
The reason was that the GOP was allegedly looking for an excuse to close the borders and further their anti-immigration agenda, and used the pandemic as an excuse.

"The president’s chief adviser on immigration, Stephen Miller, had long tried to halt migration based on public health, without success. Then came the coronavirus."[1]

"The idea that immigrants carry infections into the country echoes a racist notion with a long history in the United States that associates minorities with disease."[1]

[1]: https://www.nytimes.com/2020/05/03/us/coronavirus-immigratio...

Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Thursday November 25, 2021 @06:38PM (#29346089)
First hit in the first page of a simple google search.

https://www.nbcnews.com/politics/congress/xenophobe-chief-de...

Weird you have no recollection of it. It was pretty loud in the media for a while there.

Re:Heavily mutated coronavirus variant puts scientists on alert by tcbawo on Thursday November 25, 2021 @08:14PM (#29346655)
This article comes from April 21, 2020, not Feb 2020 as GP mentioned. Apparently it was a Democrat response to a tweet announcing a border closure after the US had already seen 42000 deaths (fta). This looks like Democrats criticizing a policy of shutting the barn door after the animals had already left the barn.
Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Thursday November 25, 2021 @10:35PM (#29347300)
No it doesn't it looks like recklessly spreading disinformation during a crisis purely for personal political gain.

The US has had strict border restrictions on foreign citizens through most of 2021 too. So unless you are going to call the Biden administration racist and xenophobic as well, then this reasoning doesn't work. But even if you did, then what you're saying about barn doors still contradicts what most experts have said in terms of reducing the movement of people to slow the spread.

Re:Heavily mutated coronavirus variant puts scientists on alert by ardit33 on Thursday November 25, 2021 @06:40PM (#29346107)
Didn't Nancy Pelosi go to hug people in China town in late Feb 2020?

Nancy Pelosi Visits San Francisco's Chinatown Amid Coronavirus Concerns https://www.nbcbayarea.com/news/local/nancy-pelosi-visits-sa...

"Fear of the Virus is Racially Motivated."

Around the time the Trump administration announced the travel restriction, Biden said that Trump had a “record of hysteria, xenophobia, and fear-mongering.”

In late January, the Trump administration implemented a travel restriction from China, where the coronavirus originated.

Some on the left described the move as a racist or xenophobic ploy aimed at punishing a country that Trump has clashed with over trade.

https://thehill.com/homenews/campaign/498350-biden-trumps-co...

Re:Heavily mutated coronavirus variant puts scientists on alert by SamoyedFurFluff on Thursday November 25, 2021 @07:06PM (#29346262)
I mean, it was true that shutting down the border to China was mostly a policy based on xenophobia than any actual facts, because at that point the vast majority of people spreading Covid into the US werent the Chinese. The huge NYC early spike started from an traveler from Europe.
Re:Heavily mutated coronavirus variant puts scientists on alert by tomp on Thursday November 25, 2021 @07:35PM (#29346456)
This is unlikely to be true and probably an attempt to rewrite the history based on current knowledge and hate of Trump.

The reality is, that back then, there was simply no better information than "coming from China". It wasn't based on xenophobia at all, just on common sense (that seemed to defy the Democrats / mainstream media). In beginning of March, Trump also closed borders to Europe. Xenophobic? No, Europe was having a spike (e.g. Bergamo, Italy). EU "president", Ursula von der Leyen, criticised the decision. 2 weeks later, EU closed its borders. (Ursula is another person that prefers politics to common sense.)

Re:Heavily mutated coronavirus variant puts scientists on alert by _djo_ on Thursday November 25, 2021 @08:38PM (#29346778)
It actually is true, the US’s SARS-CoV-2 lineages were predominantly from Europe. Especially Italy.
Re:Heavily mutated coronavirus variant puts scientists on alert by makomk on Friday November 26, 2021 @04:52AM (#29348821)
There's some evidence in retrospect that a lot of the spread to the US was from Italy. There wre two huge problems with using that as proof Pelosi and co were right to call the travel bans xenophobic. Firstly, it suggests the US policies basically succeeded at stopping the virus spreading there from China whilst Italy failed (and likely doomed the rest of the world in the process). Secondly, in order to block travel from Italy early enough, the US would've had to do it when Italy was consistently reporting zero cases week after week. Given that pretty much the entire US mainstream media and political insisted that it was xenophobic and unjustified to stop travel from Europe even after there was evidence of a major outbreak, I can't imagine there'd be much support for doing so when Italy reported zero cases and the US had cases from China - even though the reason for that was that Italy was doing worse at detecting outbreaks and those local cases turned out to be much less of a problem than ones from zero-case Italy.

Something seems to have gone really badly wrong in Italy and it's somehow gone entirely unexamined by the media, despite the fact that it did more to doom the rest of the world's efforts than any of the countries that have been blamed for doing so. Entirely unrelately, Italy is lead by the kind of boring technocrat that the media likes rather than some Trumpian populist figure.

Re:Heavily mutated coronavirus variant puts scientists on alert by johncena33 on Thursday November 25, 2021 @07:26PM (#29346394)
Yes, despite of all the cover-ups and lyings China is never responsible. And everyone else is responsible for pandemic.
Re:Heavily mutated coronavirus variant puts scientists on alert by evan_ on Thursday November 25, 2021 @06:41PM (#29346115)
It’s an intentional misrepresentation of Pelosi and others decrying violence against Asian people.
Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Thursday November 25, 2021 @06:50PM (#29346167)
Your comment violates the HN guidelines which are available here. https://news.ycombinator.com/newsguidelines.html

Please respond to the strongest plausible interpretation of what someone says, not a weaker one that's easier to criticize. Assume good faith.

(and several others)

Re:Heavily mutated coronavirus variant puts scientists on alert by frenchyatwork on Thursday November 25, 2021 @06:12PM (#29345899)
Yes, but none of those "experts" were calling it "a normal seasonal virus", they just didn't believe such measures were necessary. SARS-COV-1 didn't require widespread border closures or masking, and it very much wasn't "a normal seasonal virus".
Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Thursday November 25, 2021 @06:32PM (#29346040)
Yep so the rhetoric about it could easily have lead someone to think it wasn't much more to worry about than the seasonal flu.
Re:Heavily mutated coronavirus variant puts scientists on alert by tempestn on Thursday November 25, 2021 @06:40PM (#29346104)
That's fair, but when people have opinions based on weak evidence, they should hold those opinions weakly, rather than reinforcing them to others.
Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Thursday November 25, 2021 @06:43PM (#29346123)
Are you criticizing the experts here? Careful that's verboten.
Re:Heavily mutated coronavirus variant puts scientists on alert by tempestn on Friday November 26, 2021 @05:50AM (#29349084)
I'm not, no. As more evidence is accumulated to support a hypothesis, it is rational to strengthen one's belief in it. All beliefs should start out weakly held, until sufficient evidence is gathered to either reinforce or change them. And of course even strongly held beliefs should be re-examined if sufficient evidence piles up to the contrary.
Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Friday November 26, 2021 @06:05AM (#29349146)
So the incorrect opinions based on weak evidence that the experts had over the past years of covid should not have been "reinforced to others"? That sounds to me like a criticism of the experts.
Re:Heavily mutated coronavirus variant puts scientists on alert by tempestn on Friday November 26, 2021 @03:38PM (#29353848)
No, the experts were disseminating the best available evidence at that time. I will criticize some steps by policy makers, like stating initially that masks were ineffective when in reality they were trying to discourage mask shortages to keep them for essential workers. I think in cases like that it's better to be honest with the public. But I don't have any criticism for scientists who accurately portray the best available evidence at a given time.

My criticism was for the the hypothetical that the OP may have rationally stated that the virus was nothing more serious than a seasonal flu, based on experts stating that borders should not be closed. The statement that borders should not be closed was based on the most relevant research at the time; it turned out to be incorrect and was later reversed. But as a lay person, making the jump from that statement to the opinion that the virus is no big deal, and then echoing that opinion to others as fact, is not rational. One might have taken it as weak evidence in that direction, but no more than that.

Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Friday November 26, 2021 @06:28PM (#29355385)
If "experts" were saying not to wear masks, insisting that border restrictions were racist and xenophobic, telling people to go out and gather in large groups in public, then OP said absolutely nothing wrong by claiming it was no more serious than the seasonal flu.

Now we know that some "experts" were just totally wrong and had no idea what they were talking about, and others were in fact spreading misinformation abouta pandemic for political gain. But that is not OP's fault. You can't condemn him and absolve the actual people who reinforced that incorrect information to him in the first place. Ludicrous.

Re:Heavily mutated coronavirus variant puts scientists on alert by tempestn on Friday November 26, 2021 @11:33PM (#29357448)
From the very early days of the Wuhan outbreak it was clear, and was the consensus of experts, that the virus was much more serious than a seasonal flu. There was indeed disagreement as to the best ways to combat it, but it was not said (by anyone credible that I saw) nor implied that the virus itself wasn't serious. I'm sure you could find an occasional counter-example, as there are going to be people in any field who are wrong about any given subject, but the consensus was pretty clear. (Note that I'm talking about actual experts, not politicians or pundits.)
Re:Heavily mutated coronavirus variant puts scientists on alert by throwawaylinux on Saturday November 27, 2021 @02:14AM (#29358241)
What data do you base your claims on?

Studies like this one, https://journals.plos.org/plosone/article?id=10.1371/journal..., do not support what you are saying. Experts predicted 30,000 people would die from covid in the UK by the end of 2020, compared with yearly deaths from influenza which is usually quoted at about 25,000-30,000.

Re:Heavily mutated coronavirus variant puts scientists on alert by culi on Thursday November 25, 2021 @06:22PM (#29345973)
What were your thoughts on it in February 2020?
Re:Heavily mutated coronavirus variant puts scientists on alert by dham on Thursday November 25, 2021 @08:37PM (#29346772)
Bill Maher said it best. "Before you get sick you are sick. This is a very sick country, still is, I don't mean mentally, but physically"

We were already dying before February 2020. America is fat and we'll never get universal healthcare because people can't take responsibility for their actions. 80% of people who died from this thing were obese. If it hit 40 years ago it would have been nothing or similar to Hong Kong Flu

Re:Heavily mutated coronavirus variant puts scientists on alert by dekhn on Thursday November 25, 2021 @07:05PM (#29346257)
in feb 2020 I knew this wasn't going to be an existential crisis (IE, it wasn't going to kill 90% of people,and if the economy tanked, it wouldn't be because the virus itself was so virulent) and that ultimately it would begin to look more like other persistent viruses. This whole thing has played out more or less like I expected based on my prior experience with viruses.

I am not happy that the people announced this did so with scare tactics (specific wording) rather than emotionless facts.

Re:Heavily mutated coronavirus variant puts scientists on alert by jacquesm on Thursday November 25, 2021 @07:31PM (#29346425)
Ok, but that leaves the option that it kills up to 10% of the people and I can guarantee you that if that ends up being the case a lot of people will feel that we should have probably taken things a bit more serious in March 2020.

Emotionless facts can be scary in their own right.

Re:Heavily mutated coronavirus variant puts scientists on alert by dekhn on Thursday November 25, 2021 @07:57PM (#29346578)
10% of what people? That doesn't match up with any stats that I'm aware of. Unless you mean "it kills up to 10% of people within certain population demographics" which is my point- and it's entirely uninteresting.

I think US public health officials and generally in europe the leadership all pursued the most reasonable path and it's unlikely we could have reduced the overall death load significantly through any intervention short of extreme isolation. It is very unlikely that mainstream science will conclude, in a decade, that we could have taken actions that would have greatly reduced the spread and impact, without also applying highly restrictive rules.

Re:Heavily mutated coronavirus variant puts scientists on alert by jacquesm on Thursday November 25, 2021 @08:00PM (#29346588)
> Unless you mean "it kills up to 10% of people within certain population demographics" which is my point- and it's entirely uninteresting.

Then I don't think we're going to end up being in agreement. To me the world isn't a science experiment where some outcomes are interesting and others are uninteresting when it comes to the deaths of millions of people. Call me a softie if you wish.

Re:Heavily mutated coronavirus variant puts scientists on alert by dekhn on Thursday November 25, 2021 @08:09PM (#29346638)
Please point to the source of your 10% stat.

Obviously it's terrible that millions of people died. But then, millions of people died from the black plague, many die from car accidents, and preventable (via lifestyle changes) diseases. As an ex-scientist I work hard to take the long view on disease- that is, billions of years. Once you adopt this perspective and look at COVID, you realize that many aspects of it have been overreported in the press and that led many people to overestimate its relative danger compared to many other things we face on a regular basis.

  The current reporting about the newest virus is a great example- the language is scary, but we have absolutely no data to tell us that this will have any global impact, nor that this represents any sort of phase change into a new situation.
Re:Heavily mutated coronavirus variant puts scientists on alert by jacquesm on Thursday November 25, 2021 @08:16PM (#29346663)
Your own comment. 100% - 90% = 10% and that was marked as just a possibility.

> As an ex-scientist I work hard to take the long view on disease- that is, billions of years.

That's fine, but that timescale is not the timescale at which our lives are unfolding.

> Once you adopt this perspective and look at COVID, you realize that many aspects of it have been overreported in the press and that led many people to overestimate its relative danger compared to many other things we face on a regular basis.

Well, even if I take the most conservative figures I end up with millions of 'front-loaded' deaths, and 100's of thousands of deaths where 'premature' is probably an accurate figure. And that's before we get to take into account that this is long from being over.

> The current reporting about the newest virus is a great example- the language is scary, but we have absolutely no data to tell us that this will have any global impact, nor that this represents any sort of phase change into a new situation.

That is absolutely true. But at the same time we also don't have any data for the opposite: that this will not affect things at all. Policy makers are in a bind, anything they do that helps will come with a price tag, the cost of doing nothing is likely political suicide, the cost of doing too much is going to come at the price of a massive global recession (and possibly set the stage for future wars).

So now we get this stretched out slow motion train wreck, which is far from ideal as well. What would you suggest we do instead?

Re:Heavily mutated coronavirus variant puts scientists on alert by dekhn on Thursday November 25, 2021 @08:25PM (#29346701)
My suggestion (and I strongly recommend nobody takes it) is to immediately go forward with no masking, no vaccination, special triage centers for people with COVID (so they aren't infecting people with comorbidities going to hospitals), accept the catastrophic loss of life, and then watch carefully over the next ten years. My belief is that if this happens, the entire global population will have enough natural immunity that this disease will become endemic.

As I said, nobody should follow my advice. it would be political suicide- in the same way that people who promote "death panels" (to allocate limited resources rationally) get shut down, even though it's the most rational approach that would maximize global health.

Further, everything I suggested above is merely intuition based on several decades of experience working in public health/medical biology, rather than hard epidemiological data. I could be completely wrong and my strategy could instead lead to a black death scenario or existential situation (death rates of 30+% due to virulent variants with high transmission rates and very long infectious periods). Again, I must say that nobody should follow my recommendation because it's based entirely on a lifetime of systems thinking and working with complex biological entities.

Re:Heavily mutated coronavirus variant puts scientists on alert by jacquesm on Thursday November 25, 2021 @08:28PM (#29346719)
It's a bit strange to see a suggestion like that accompanied by the disclaimer that it shouldn't be taken. What scenario would you suggest that is not accompanied by such a disclaimer? In other words, say we put you in charge of public policy tomorrow without the option to abdicate, what would you suggest we do, assuming it would actually be done as you advise?
Re:Heavily mutated coronavirus variant puts scientists on alert by dekhn on Thursday November 25, 2021 @08:45PM (#29346807)
Build a time machine and invest more in the CDC and the NIH back in 1985?

Seriously though I can't think of a more reasonable strategy than that carried out by the US, Sweden, and China (each represents a different experiment).

China's extreme level of population restriction and high level of testing seems to have greatly reduced transmission and impact (I don't know how to interpret China's published numbers, and I don't really trust them that much). This is probably necessary in any area where population density is high enough that rapid transmission can occur. However, my guess is that it also led to a large number immune-naive people and I don't think that any current vaccine will be useful for more than a year, so I think they're at constant risk of explosive disease growth that they can only address through strict policies.

For countries with fairly small number of dense cities, like Sweden, I think what they did was excellent. They stated their prior beliefs and more or less stuck to them and, in my interpretation, they did not suffer any more than other countries, when population density is considered.

Finally, the US. The US did fairly well even though there is a large noncompliant population for a number of reasons. First, we've invested heavily in disease management infrastructure (research, hospitals, strong public health) which meant that we could deal with (to some extent) the massive surge of patients going to hospitals who then infected others nosocomically, and have industries that developed vaccines and other treatments quickly. Second, we actually have a well organized public health system that is relatively powered to implement unpopular but reasonable policies. But, I worry that our court system moves too slowly (for example I would really like to see the supreme court making an extraordinary decision that the US has full rights to mandate vaccines for its entire population) and we have a large number of people who seem to actively fight reasonable public health measures.

So in short, the best approach is to have a large amount of resources (public health researchers, medical folks) combined with excellent realtime knowledge about spread, a largely compliant population which is willing to suspend civil liberties in emergency situations, and political leaders who are willing to risk their long-term careers by providing cover for the researchers.

Finally, thank goodness that the US had the foresight to make and fund the NIH and CDC for so long, providing us with an excellent foundation with which to respond to diseases like this. I am in awe of the folks who pushed for the creation of a new field (molecular biology) in the 30s and 40s which led to the elucidation of the genetic code and development of structural biology, which ultimately provides the foundation for much of our understanding of viruses.

Re:Heavily mutated coronavirus variant puts scientists on alert by jacquesm on Thursday November 25, 2021 @09:05PM (#29346898)
Fair enough, thank you. I like to keep things grounded in reality, theoretical considerations are fine for after the fact analysis but in a fluid situation decisions need to be made. They'll never be perfect but not deciding is abdication and that isn't really an option.

Where I live the health care system has been weakened to the point that we can't really deal with such levels of calamity in a responsible manner any more, the result of years of neo-liberal cost cutting and attempts to create a market situation around health care. The end result is a terribly fragile mix of high density populations, extreme mobility and very little cushion to absorb mistakes. It remains to be seen if either one of the three scenarios you sketched will work for us in the longer term, so far it's not looking all that good but it also could have been far worse.

Re:Heavily mutated coronavirus variant puts scientists on alert by dekhn on Friday November 26, 2021 @09:33AM (#29350519)
I have long predicted that health care will bankrupt america.
Re:Heavily mutated coronavirus variant puts scientists on alert by lozenge on Thursday November 25, 2021 @06:51PM (#29346173)
Less developed than today, can the persistent downplayers honestly say the same?
Re:Heavily mutated coronavirus variant puts scientists on alert by polote on Thursday November 25, 2021 @05:53PM (#29345787)
Doesn't seem a wrong stake, the population was naive to this virus, but except that what is special with covid?
Re:Heavily mutated coronavirus variant puts scientists on alert by nradov on Thursday November 25, 2021 @06:49PM (#29346163)
It's not very special from a historical perspective. It appears to be very similar to HCoV-OC43.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252012/

Re:Heavily mutated coronavirus variant puts scientists on alert by cortesoft on Thursday November 25, 2021 @06:08PM (#29345875)
Umm all the deaths?
Re:Heavily mutated coronavirus variant puts scientists on alert by dekhn on Thursday November 25, 2021 @07:11PM (#29346288)
Let's look back at those deaths in about 10 years. I predict that over time, epidemiologists will have much better estimates on who died of what and when and what the risk factors for death are. From what I can tell, much of the deaths are front-loaded (IE, we saw them over a few years instead of decades), and concentrated in people who had comordibities.

People evolved to respond to the flu over millenia before there was widespread travel. I think that explains much of the dynamics of covid.

Re:Heavily mutated coronavirus variant puts scientists on alert by jacquesm on Thursday November 25, 2021 @07:34PM (#29346445)
We've been working hard as society to allow people to continue to live with chronic disease. Co-morbidities is just another way of saying 'they would have died sooner or later anyway', but for all of these cases you are looking at individuals and people that have family and dependents. In the long term all deaths are 'front-loaded'. Every person that dies of traffic, obesity, terrorism, disease, famine and so on would have eventually died anyway from some other cause. That doesn't stop us from trying to address these causes of death resulting in people living longer. We don't call those who live to an older age with diabetes 'time stealers' any more than we should call people that die early of COVID+some other factor 'front loaded'.
Re:Heavily mutated coronavirus variant puts scientists on alert by cortesoft on Saturday November 27, 2021 @02:42PM (#29362761)
I really hate this argument (that people who die of Covid would have died soon anyway). Everyone will die eventually, so let's not treat any disease? Let's withhold all medical care from people over 80... almost all of them will be dead in 10 years, why treat them?

A premature death is a premature death, no matter how many years it cuts off.

Re:Heavily mutated coronavirus variant puts scientists on alert by tigershark on Thursday November 25, 2021 @05:57PM (#29345811)
Nothing, we didn’t have the whole world locked down for 1 year for the first time in a pandemic…
Re:Heavily mutated coronavirus variant puts scientists on alert by jacquesm on Thursday November 25, 2021 @07:35PM (#29346451)
We didn't this time either.
Re:Heavily mutated coronavirus variant puts scientists on alert by ummonk on Thursday November 25, 2021 @07:06PM (#29346263)
"the population was naive to this virus"

That's precisely what made it abnormal. The population isn't naive to normal seasonal viruses.

Re:Heavily mutated coronavirus variant puts scientists on alert by guscost on Thursday November 25, 2021 @08:34PM (#29346753)
Here’s what I wrote in May 2020 (I underestimated both the seasonality, and the speed of mutations, at least): https://guscost.com/2020/05/12/pandemic-woo/
[dead]
Re:Heavily mutated coronavirus variant puts scientists on alert by kadoban on Thursday November 25, 2021 @06:26PM (#29346002)
What? Please point to any time anywhere near there, that Anthony Fauci has called Covid a "normal seasonal virus".
Re:Heavily mutated coronavirus variant puts scientists on alert by idlewords on Thursday November 25, 2021 @05:57PM (#29345809)
If they post here I'll zing them too
Re:Heavily mutated coronavirus variant puts scientists on alert by chitowneats on Thursday November 25, 2021 @06:00PM (#29345830)
On what basis? Have you offered evidence of your thoughts during that time? Does that even matter?

Hindsight is 20/20. I hope that most of HN will forgive me for questioning the notion that u/idlewords is somehow entitled to disqualify others from this discussion about variants.