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Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by goodroot on Wednesday November 10, 2021 @12:19PM (#29177296)
> 25mg psilocybin isn't something you can just pop at the beginning of a workday.

I would disagree. For many, 25mg is sub-perceptual.

Source: have done this over several year.

Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by WalterSear on Wednesday November 10, 2021 @12:31PM (#29177438)
3-5 grams of mushrooms?

I want to work where you work. I hope it doesn't involve heavy machinery.

Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by me_me_me on Thursday November 11, 2021 @05:57AM (#29186649)
it depend on your weight, and potency of batch.

I have settled on 2g every 3rd day. 1g dose seems to work only on empty stomach and I have to pay attention to feel difference in my mood.

I can easily see a big guy taking 3-5g and not feeling much beyond mood boost.

Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by nobodyofnote on Wednesday November 10, 2021 @01:33PM (#29178425)
I think you're confusing 25mg of psilocybin with a microdose of 25mg of dried mushrooms. 25mg of pure psilocybin is anything but sub-perceptual.
Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by goodroot on Wednesday November 10, 2021 @05:44PM (#29181986)
Ahhh - yes, missed this.

Holy hell, yeah that'd blow the roof off for sure.

Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by OnACoffeeBreak on Wednesday November 10, 2021 @01:27PM (#29178332)
I am guessing the 25 mg does here is of pure psilocybin, which is about 2.5 g of dried mushrooms.
Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by tayo42 on Wednesday November 10, 2021 @12:40PM (#29177575)
20-something mg of 4aco dmt was pretty wild, psilocybin must be somewhat similar