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Re:Biden to mandate coronavirus vaccine for federal workers by michaelt on Thursday September 09, 2021 @03:19PM (#28473557)
You're absolutely right - getting vaccinated protects your family, your community, and your country.

What I mean by punching yourself in the face is: Even if you don't have any family and you hate your neighbours, getting vaccinated is still in your own interests, because it stops you dying.

Re:Biden to mandate coronavirus vaccine for federal workers by nradov on Thursday September 09, 2021 @04:55PM (#28474549)
I encourage everyone to get vaccinated if they can, but it's unclear what community protection that provides. Vaccinated people can still get infected and spread the virus. They may be contagious for a shorter period on average but the magnitude is still unknown.

https://www.nature.com/articles/d41586-021-02187-1

Since the Delta variant is so contagious there will be no significant herd immunity effect to protect the unvaccinated. The virus is now endemic and can't be eradicated so all of us can expect to be exposed multiple times throughout our lives.

https://www.businessinsider.com/delta-variant-made-herd-immu...

Re:Biden to mandate coronavirus vaccine for federal workers by lamontcg on Thursday September 09, 2021 @05:21PM (#28474818)
Vaccination almost certainly reduces transmission.

https://www.timesofisrael.com/80-of-vaccinated-covid-carrier...

RNA levels spike to the same levels on PCR, but they decline faster, and culturable amounts of virus are lower in breakthrough infections, indicating a higher proportion of viral debris in breakthrough infections rather than virus:

https://www.medrxiv.org/content/10.1101/2021.08.20.21262158v...

Even if you take the worst numbers out there vaccines still eliminate 50% of infections. And symptomology, viral load and transmissibility are correlated -- which means the vaccines is likely to be effictatious against transmissibility just like it is against disease.

The worst-case idea that breakthrough infections, even though they're much less severe, produce identical risk of transmission does not make any sense at all.

I would bet money that if everyone was vaccinated that the R0 of delta would be less than 1.0 and we would not have epidemic spread and that breakthrough superspreaders are incredibly rare.

Re:Biden to mandate coronavirus vaccine for federal workers by nradov on Thursday September 09, 2021 @05:42PM (#28475016)
What is your scientific basis for betting that Prof. Pollard is incorrect? Even though vaccination likely reduces the risk of transmission, we have no evidence that even a very high level of vaccination would be sufficient to reduce R0 below 1.0. It's impossible to reach 100% coverage and even countries with high vaccination levels are still experiencing uncontrolled community spread. We can flatten the curve to an extent (useful for reducing impact on the healthcare system), but it's unlikely that we can significantly reduce the area under the curve.
Re:Biden to mandate coronavirus vaccine for federal workers by lamontcg on Thursday September 09, 2021 @06:23PM (#28475351)
What evidence does he have of actual transmission? I want to see actual studies with humans with breakthrough infections giving infections to other humans. I'd like to see one contact tracing case where a breakthrough infection was the index patient that spread it to multiple people at a given venue.

I've already posted studies which contradicts the idea that breakthrough infections are equivalent to unvaccinated infections in terms of actual live viral load, which should show up as reduced transmissibility. And the reduction in severity of symptoms with vaccination is highly unlikely to come without a corresponding reduction in transmissibility. What is his scientific data showing that viral loads, symptoms and transmissibility have somehow become completely decoupled?

And we seem to have forgotten that most of the spread of this disease is caused by individual superspreaders. Only 20% of the infections are responsible for 80% of the forward transmission. If vaccines reduce severe transmission the same way they reduce severe disease then they could very well have a disproportional impact on r0.

> It's impossible to reach 100% coverage

The fact that we can't hit 100% coverage doesn't imply that vaccines in the population that we can vaccinate aren't highly effective at reducing transmission.

Also if you're just making an argument by authority, then go watch all the recent TWiV episodes. I don't necessarily agree with Herr Professor Doktor Racaniello about everything (delta really is a lot more transmissible/virulent), but the whole crew there would tend to agree with me, and wants to see the real transmissibility studies with real humans infecting real humans.

Re:Biden to mandate coronavirus vaccine for federal workers by nradov on Thursday September 09, 2021 @08:31PM (#28476416)
This is not an argument by authority. There is strong evidence of significant Delta variant transmission by vaccinated people.

https://www.nature.com/articles/d41586-021-02187-1

https://www.cdc.gov/coronavirus/2019-ncov/vaccines/effective...

https://doi.org/10.1101/2021.07.31.21261387

Re:Biden to mandate coronavirus vaccine for federal workers by lamontcg on Friday September 10, 2021 @01:12PM (#28484477)
That nature article is still repeating arguments which conflate studies of Ct values of RNA with infectious virus and don't address the fact that vaccines reduce symptoms and that Ct values drop faster in vaccinated individuals.

The CDC article doesn't say anything other than "People who get vaccine breakthrough infections can be contagious" without any citation.

The actual study you cite only tests for viral RNA not infectious virus, they only cultured a single sample from a breakthrough infection to show that it could happen.

Other studies have found that viral RNA drops faster in vaccinated individuals, and that levels of culturable virus are lower at peak in vaccinated individuals indicating the presence of more viral debris than infectious virus:

https://www.medrxiv.org/content/10.1101/2021.07.28.21261295v...

https://www.medrxiv.org/content/10.1101/2021.08.20.21262158v...

We also know that viral loads are correlated with transmissibility and symptoms, and that vaccines reduce severe symptoms. We know there's less infectious virus in breakthrough infections and that they're less severe. It is rational to expect a reduction in transmissibility.

Re:Biden to mandate coronavirus vaccine for federal workers by croon on Friday September 10, 2021 @04:56AM (#28479186)
The point is; Is it more (/less/no change) transmittive vaccinated vs unvaccinated? If it lowers transmittion only a tiny bit it's still net positive.
Re:Biden to mandate coronavirus vaccine for federal workers by simonh on Friday September 10, 2021 @11:24AM (#28482865)
I'm afraid you're probably correct. I fully support vaccination, am vaccinated and support vaccine mandates. Still, the fact is here in Britain high vaccination rates are not stopping the propagation of the virus. Maybe if we also had a full lockdown as well that combined with vaccination might stop it spreading, but that's not a reasonable policy given the low risk of the virus to the vaccinated population and young people.
Re:Biden to mandate coronavirus vaccine for federal workers by nradov on Friday September 10, 2021 @12:48PM (#28484113)
A full lockdown is not practical, nor would it be effective. SARS-CoV-2 has multiple animal reservoirs. So even if we could somehow eliminate it from all humans simultaneously (we can't), someone would just catch it from an animal again and the whole pandemic would restart. The bats which presumably transmitted it to humans in 2019 are still out there somewhere.
Re:Biden to mandate coronavirus vaccine for federal workers by lamontcg on Friday September 10, 2021 @01:21PM (#28484591)
You still don't have high enough vaccination rates.

All the kids under 16 have a vaccination rate of 0% and they still count and they commingle and provide a reservoir. The vaccination rate in 16-25 year olds is also probably not high enough to achieve herd immunity with delta. It isn't a particular mystery why its still spreading unless you assume kids don't exist.

A single number for vaccination status and herd immunity would only be meaningful if the population was randomly well-mixed. In reality kids are much more likely to see other kids every day than hang out with the elderly.

Re:Biden to mandate coronavirus vaccine for federal workers by simonh on Friday September 10, 2021 @02:19PM (#28485280)
Estimates for case rates among under 16s are up to 50%, half of them may well have had it already. They also fight it off fairly quickly and the vaccine doesn't stop you getting it. Add all that together and there rally doesn't look like a compelling case for vaccing kinds, at least in the UK.

We are rolling it out to 16-17 year olds, which happens to be the ages of my kids and both had their first shots about a week ago. There may be some marginal benefit for youngsters, but those dose are better deployed elsewhere. Over 17s are already well vaccinated here.

I'm not at all anti-vaccine, they've transformed the UK, but there's just no point vaccing under 16s. We're deep into diminishing returns with that, and those doses are sorely needed in many other countries.

Re:Biden to mandate coronavirus vaccine for federal workers by michaelt on Thursday September 09, 2021 @06:37PM (#28475488)
> it's unclear what community protection that provides

Maybe against community spread of infection.

The protection vaccines provide against overloaded hospitals, tragic avoidable deaths and paralysing additional lockdowns and mask policies is clear, though.

Re:Biden to mandate coronavirus vaccine for federal workers by angelzen on Thursday September 09, 2021 @09:23PM (#28476736)
The Yale/Harvard/Stanford team at https://covidestim.org estimates that R has receded under 1 for most states / counties. Much better than a month ago. This is a good indication we are past peak delta. The medical system was stretched in places, but held. While the vaccines help keep the pandemic under control and the human cost bearable, it doesn't follow that we need 100% vaccination rate for community protection.
Re:Biden to mandate coronavirus vaccine for federal workers by makomk on Friday September 10, 2021 @05:37AM (#28479398)
Not only that, but there seems to be a campaign against the press actually informing people about the limited effectiveness of the vaccine at preventing infection and spread. The stat that actually matters is the relative reduction in risk of vaccinated people catching Covid-19 compared to unvaccinated - it's what dictates things like whether it's possible to get herd immunity via vaccination, and whether events that would turn into superspreading incidents without vaccination still will now. But there's this narrative being pushed that it's wrong and misleading based on nonsense stats like the total percentage of cases which were unvaccinated over a time period that includes a major wave which ended before widespread vaccinations were available, or the absolute risk of someone who's vaccinated catching it (which is worthless as it depends mostly on the prevalence of the virus, and Covid spreads exponentially).

This all seems to be done in order to blame unvaccinated people - and more specifically unvaccinated Republican voters - for the fact that Covid is still spreading and causing deaths and economic damage. (Vaccination rates are also dangerously low amongst black Democrat voters, but of course it'd be politically unacceptable to blame them in the same way). The press keeps pushing the narrative that we could end Covid and all the damage it's doing if not for those evil unvaxxed people, even though this doesn't seem to be borne out by the experience of countries with higher vaccination rates or the scientific evidence.

Re:Biden to mandate coronavirus vaccine for federal workers by vlovich123 on Friday September 10, 2021 @02:40AM (#28478450)
Humans are not rational creatures. Our beliefs can override rationality & that's true regardless of how smart you think you are. That's why you have Christian Scientists being convicted for child abuse/neglect for not providing a reasonable standard of medical care ("reasonable" being defined as "commonly accepted behaviors in our society"). Similar issues around beliefs would apply around vaccines, especially with extremely high levels of mistrust of the opposite party AND a historic amount of anti vaxxers generally. Would Democrats be accepting the vaccine so quickly if the bulk of the rollout happened under Trump? I don't know but I certainly had misgivings that the Trump government was playing politics fast-tracking the vaccine that evaporated when Biden came to power for some reason. I probably would have still taken the vaccine, but is that because I'm being rational or because I'm anti anti-vaxxers?
Re:Biden to mandate coronavirus vaccine for federal workers by bradlys on Friday September 10, 2021 @03:28AM (#28478696)
There is some just skepticism of anything that happens under Trump. The dude talked about injecting bleach into your veins. Come on.
Re:Biden to mandate coronavirus vaccine for federal workers by loonster on Friday September 10, 2021 @08:39AM (#28480672)
He never talked about putting bleach in your veins. He spoke about putting UV light and disinfectants inside the body. Both are obscure, but real treatments.

Edit: https://youtu.be/zicGxU5MfwE

Re:Biden to mandate coronavirus vaccine for federal workers by croon on Friday September 10, 2021 @08:49AM (#28480777)
This is Trump minutes before the infamous quotes:

https://ichef.bbci.co.uk/news/976/cpsprodpb/AA47/production/...