but we actually won that war, which precipitated a rise to global hegemon status. covid has been a pathetic, fumbling showing, one that clearly reflects institutional decay and foreshadows future decline -- the reverse of the first situation
If you look back at history through rose-tinted glasses everything will appear better than it was.
I'm obviously not happy with the state of the world as a computer scientists.
I mention all of that because even that wobbly claim was still couched in terms like “did” or “could” while the comment I replied to described it as “likely prevailing truth”. We have no evidence and limited data supporting that hypothesis and a number of people pushing it for political reasons, which is rarely helpful to the scientific process.
1. https://nautil.us/issue/102/hidden-truths/when-a-good-scient...
Against a totally novel virus, we developed and widely deployed vaccines with efficacies beyond anyone’s wildest dreams using totally novel technology in the span of a year. Not sure that quite meets my definition of “pathetic.”
What was pathetic was the federal coordination - hesitation on travel restrictions, CDC response, recommendations against PPE… Lessons that could have been learned even from the 1918 pandemic were painfully ignored.
From a book on this subject: "Another problem in the country's preparation was the production of uniforms similar to those of the German Army. 'They even threw rocks at us in Naples thinking we were the invaders'.”
I thought the rollout of the vaccines in the time it took, with the effectiveness it had, just went to show how the knowledge and technology of vaccines makes it one of the greatest human achievements, ever.
Public authorities largely claimed it wasn't happening and wasn't a big deal as hospitals overflowed and we dug mass graves.
They even cancelled public gatherings but pretended it was unrelated to a health crisis. Health responses in the us were completely scattershot, and no one trusted information coming out from the government.
Compared to that this response was actually far better and more organized.
I'm actually a little worried about this. Of course, I'm happy it'll boost interest in vaccine development. But the terror and fear in reaction to AIDS led to a general biosecurity obsession that became biosecurity paranoia and then hysteria and then a renewal of persecution of homosexual men for a couple decades. Who says we'll be immune to the worse effects of fear, paranoia and panic this time around?
mRNA vaccines just get your body to produce a particular protein you want to induce an immune response to, instead of injecting the protein directly.
Is it really the slow uptake of mRNA techniques that's prevented an HIV vaccine? Or is it HIV's capacity for rapidly mutating into large numbers of disparate strains inside one person, let alone in the entire community?
I mean, look at the delta variant of Covid, the mRNA vaccines reduce the severity of infection, but do not prevent infection or spreading thereof.
mRNA vaccines will enable rapid iteration, which is good. But they're not a wonder drug at all.
I keep seeing that surface here. It is at odds with what I'm reading that says it /is/ effective at preventing infection[1] though not perfectly so. Are we looking at different metrics, or is my own ignorance of the field preventing me from fully understanding what I"m reading?
[1] most recently - https://www.cdc.gov/mmwr/volumes/70/wr/mm7034e5.htm?s_cid=mm...
mRNA vaccine tech being discussed here is not gene therapy. It cannot (appreciably) alter host DNA the way radiation or gene therapy can. It simply causes the host cells to manufacture desired proteins for a limited amount of time.
One of the things that'll come out of this is that mRNA vaccines as miracle wonder drugs that cure everything are going to get huge amounts of attention, and media will reflect that. Especially if the Lyme, Malaria, and HIV vaccines prove successful. We are going to see mRNA vaccines as plot devices and MacGuffins in media for decades to come. It's going to get the same treatment radiation got in the '60s and '70s and genetic engineering got in the '90s and '00s. For example, it wouldn't surprise me if, the next time Marvel decides to make a new adaptation of Spider-Man, the spider will have been treated with mRNA instead of radiation (the original story) or gene therapy ('90s cartoon, '00s movies, maybe others).