it's been looked at several times, and a vast majority of the convincing evidence seems to fall in favor of the camp that overall mitigations do nearly nothing compared to control samples of places with no/fewer restrictions

https://slatestarcodex.com/2020/05/18/coronalinks-5-18-20-wh...

That article is more than a year old. A far newer, more complete assessment shows that mitigations do you have an impact in reducing deaths and infections:

https://www.medrxiv.org/content/10.1101/2021.07.28.21261286v...

Yes, but you need a control to compare it against. How do you get one?

Just look at the trend line? You might also want to look at the excess statistically significant deaths numbers.

https://www.ft.com/content/6bd88b7d-3386-4543-b2e9-0d5c6fac8...

You need controls to account for confounding factors. Looking at a trend line does not account for confounding factors.

Ok, what would be a confounding factor?