Depending on the use case, RAM disks are also pretty easy to set up for any temporary/volatile storage used by shell scripts and the like.
One RPi has been running my Home Assistant for 3 years 24/7, with a very noisy ZWave network that has debug logging on.
I had one where I _thought_ there was something weird going on with the SD card, but it turned out to be a crappy USB cable that lead to excessive voltage drop under load. Swapped the cable and it's been running my PiHole for over 2 years now on a standard Armbian+Docker install, zero issues.
Maybe I've just been lucky?
Regardless, I'm done monkeying with Pi 4s, and I'm moving to cost comparable PC Thin Clients for my self-hosting needs.
Never had any issues with several Pi3s over the years. They just don't have the oomph anymore for my needs.