News for hackers. Stuff that matters.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by mint2 on Wednesday July 28, 2021 @03:25PM (#27988512)
Given that:

A. Pfizer isn’t the only vaccine option.

B. If one doesn’t take the vaccine, one’s chances of dying or being disabled for years or permanently are much higher.

C. If one doesn’t take the vaccine there is a significant chance they give the virus to someone else, killing them.

I think it’s the best option out of all non-great options to mandate vaccines in order to participate in crowded settings. It’s a matter of civic responsibility in order to partake in civic life. Sure it would be better if there was no Covid so no one would need an extra vaccine, but that world no longer exists. I don’t like the current situation either but it is what it is.

Civic responsibility isn’t brought up much these days. Liability shield for vaccine makers isn’t fair, but unvaccinated allowed to romp around spreading the virus without liability is also not fair.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by incrudible on Wednesday July 28, 2021 @03:47PM (#27988824)
Pfizer and Moderna have similar risk profiles, everything else seems to be much worse. Argument B is highly subjective and I would argue that "the data isn't there" for the young and healthy parts of the population. Despite being "safe and effective" by the standards of medicine, a Sars-COV2 vaccination also carries a non-zero risk of disability and death. Argument C doesn't really cut it, because "someone else" should've gotten the vaccine themselves, if they're at risk.

It's now becoming obvious that vaccinated individuals can still be infected and can spread the infection as well. At the same time, mortality is greatly diminished. At that point, we have a vague and unspecific reduction of an already modest risk. This is insufficient to make a "civic responsibility" argument. By the same token, I could argue people should not drive cars as a matter of civic responsibility, because that carries a non-zero risk of killing a pedestrian.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by swader999 on Wednesday July 28, 2021 @03:58PM (#27988967)
Risk of car death was actually similar where I live to death from covid for my age.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by mint2 on Wednesday July 28, 2021 @05:51PM (#27990207)
Elsewhere in the replies to my comment there are plenty of responses to your first paragraph, please browse them if you’re interested in why those criticisms of ABC are not good and miss some crucial aspects of it.

But the analogy to cars is flawed. A more equitable one would be to obey traffic laws and not do things like speed or lane jump. I.e driving in a responsible manner that is considerate of others safety. It doesn’t reduce traffic accidents to zero, it minimizes them. Your analogy would be like continuing the lockdown for vaccinated people because even vaccinated people can in rare cases spread the disease. That is as wacky as forbidden people to drive. Having people vaccinated to partake in large gatherings is like requiring people to obey speed limits or face a penalty. Sure some people will get around it.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by jonhohle on Wednesday July 28, 2021 @10:55PM (#27992306)
The “rare” cases of vaccinated individuals infecting others are neither enumerated or fully understood. In fact, until this week the CDC seemed to downplay the idea that vaccinated individuals _could_ spread the virus. Now they seem to be so concerned about it that one of the banner benefits of being vaccinated - not having to wear a mask in public settings - has been rescinded.

At the same time employers now seemingly want to be on the hook for any communicable diseases spread on company property or function. People are being coerced into disclosing medical information or risk being treated like pariahs. It cannot be understated that people are being pressured into getting an unapproved (EUA is not approval) gene therapy (FDAs classification, not mine) that has never been widely tested in humans and has non-trivial side effects. This is unprecedented, at least in the US.

This is on top of being constantly mislead by media and government officials. NPR recently gave a stat, something to the effect of “young people under 40 make up half the positive COVID cases”. Sounds alarming, except that demographic makes up half the population _and_ that demographic had disproportionately mild symptoms from the disease.

If you want to be vaccinated, please go right ahead. But then stop. Allow others that you are not the guardian of to make their own health choices based on their personal research or decision making process.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by mrhands69 on Wednesday July 28, 2021 @03:55PM (#27988933)
Show people mortality rates for various things around the world. I wonder how the ones banging the "civil responsibility" drum would react.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by pan69 on Wednesday July 28, 2021 @05:57PM (#27990268)
The way I understand it is; you can't compare to mortality rates for other various things because these other various are spread out over a 12 month period. When there is a spike in Covid cases they all happen at the same time, which floods the health system and people die needlessly (e.g. not enough ventilators). People can get very ill (and die) from the flu as well but they don't tend to do this all at the same time (i.e. no spike) but get sick spread out over a longer period of time.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by mrhands69 on Wednesday July 28, 2021 @07:29PM (#27991055)
I'm all for the approach of not overwhelming healthcare. After the initial surge health care was not overwhelmed regardless of approaches to restrictions. Look at Florida vs California: They had same outcome with opposite approaches.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by akira2501 on Wednesday July 28, 2021 @03:32PM (#27988612)
> one’s chances of dying or being disabled for years or permanently are much higher.

What is "much higher" in a number?

> If one doesn’t take the vaccine there is a significant chance they give the virus to someone else, killing them.

"Significant" would depend on their lifestyle, would it not? Are the rural unvaccinated as "significant" as the urban unvacinnated?

> Civic responsibility isn’t brought up much these days.

Not everyone has the same idea of what civic responsibility should be, which is probably why we have to write and then enforce laws.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by TheCoreh on Wednesday July 28, 2021 @03:39PM (#27988710)
> What is "much higher" in a number?

I'm not sure about the booster dose, Delta or any other variants, but the Pfizer Vaccine has been consistently shown in several studies to reduce COVID mortality by 99%, so that number is currently ~100

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by learc83 on Wednesday July 28, 2021 @03:36PM (#27988669)
> What is "much higher" in a number?

The Pfizer vaccine as I believe 94% effective against severe disease, so around 20x higher.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by estebank on Wednesday July 28, 2021 @03:43PM (#27988778)
>> one’s chances of dying or being disabled for years or permanently are much higher.

> What is "much higher" in a number?

The analysis revealed that vaccination efficacy in terms of protection against deaths was equal to 72%, with a lower reduction of number of deaths for B.1.1.7 versus non-B.1.1.7 variants (70% and 78%, respectively). Other factors significantly related to mortality were arrivals at airports, mobility change from the pre-pandemic level and temperature.

https://www.medrxiv.org/content/10.1101/2021.05.26.21257844v...

An estimated 10,400 deaths have been averted [in the UK] as a result of the COVID-19 vaccination programme up to the end of March 2021.

https://assets.publishing.service.gov.uk/government/uploads/...

>> If one doesn’t take the vaccine there is a significant chance they give the virus to someone else, killing them.

> "Significant" would depend on their lifestyle, would it not? Are the rural unvaccinated as "significant" as the urban unvacinnated?

Living in a rural environment does not mean that the virus doesn't spread, otherwise the "Cases/Deaths per 100,000" maps at https://www.npr.org/sections/health-shots/2020/09/01/8167071... would have wide divergence per state, but they all are around 11K deaths per 100,000.

A common thing I heard from some early in the pandemic was that places with lower density would fare better, but that never made much sense to me: even if you have only 10K people in a 50 mile diameter circle, they all still shop and socialize in a handful of places.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by swader999 on Wednesday July 28, 2021 @04:01PM (#27989004)
I heard they would just experience the same infection rates but at a later date than urban which seems to have played out for the rural community I'm in.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by estebank on Wednesday July 28, 2021 @04:05PM (#27989035)
Right, that's what experts were warning, while I saw multiple people in the relevant locales holding the idea I mentioned. Was this something you didn't see in your immediate area? It would be interesting to see if there was wide regional variation on whether people felt "it won't be as bad here".
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by swader999 on Wednesday July 28, 2021 @04:17PM (#27989189)
I think generally there was an expectation that you'll be safer in the sticks. But I talked to a respected epidemiologist early on and they said they had high confidence that rural rates per 100k people would reach the same as urban, just weeks later. This did in fact play out that way when I look back at the published rates for where I live and compare it with the city two hours away. Was about a five or six week lag until we reached similar case rates per 100k.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by briefcomment on Wednesday July 28, 2021 @03:39PM (#27988702)
> B. If one doesn’t take the vaccine, one’s chances of dying or being disabled for years or permanently are much higher.

But for a young person with no co-morbidities, that chance is still basically 0%.

> C. If one doesn’t take the vaccine there is a significant chance they give the virus to someone else, killing them.

Even if others have taken the vaccine themselves? Either that particular risk is negligible if the vaccine works, or the vaccine doesn't work.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by estebank on Wednesday July 28, 2021 @03:57PM (#27988954)
>> B. If one doesn’t take the vaccine, one’s chances of dying or being disabled for years or permanently are much higher.

>But for a young person with no co-morbidities, that chance is still basically 0%.

According to table "COVID-19 Fatality Rate by AGE:" at https://www.worldometers.info/coronavirus/coronavirus-age-se..., the mortality rate for everyone under 40 years of age is 0.2%. That "is basically 0", but means that for every 1000 people infected, 2 will die. Roughly half of the US is under 40 years old (https://www.statista.com/statistics/241488/population-of-the...). If no-one had gotten vaccinated, you would expect to see 320,000 deaths in that age group. According to https://www.cdc.gov/nchs/nvss/vsrr/covid_weekly/index.htm#Se..., we've had 286,000 deaths so far in that age group.

>> C. If one doesn’t take the vaccine there is a significant chance they give the virus to someone else, killing them.

> Even if others have taken the vaccine themselves? Either that particular risk is negligible if the vaccine works, or the vaccine doesn't work.

You're forgetting the number 1 law of large numbers. Things that have a very low chance of probability happen all the time at scale. The vaccine reduces the likelihood of individuals dying by orders of magnitude, and as a group it is a great tool to reduce the R0 under 1, but contagion and transmition is still possible, and every new infection we are rolling the dice on getting "lucky" with a new vaccine resistant variant.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by briefcomment on Wednesday July 28, 2021 @04:14PM (#27989145)
From your cdc link, it looks like less than 10k people have died in the under 40 age bracket. Am I looking at the right data?

Also, are you aware you can be exposed to the virus and not be infected?

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by estebank on Wednesday July 28, 2021 @04:23PM (#27989268)
> From your cdc link, it looks like less than 10k people have died in the under 40 age bracket. Am I looking at the right data?

I added every age group between 0 and 39, but took the incorrect column (Deaths from all causes, which is obviously incorrect), which puts me off by an order of magnitude.

> Also, are you aware you can be exposed to the virus and not be infected?

That is true, like with any virus it is a statistics game. It is also true that the Delta variant is 1000x more virulent/transmissible, so likelihood of infection is much higher today than a year ago.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by mint2 on Wednesday July 28, 2021 @05:38PM (#27990070)
And since being vaccinated would have saved most of those 10k people and like a small handful have died from all of the vaccines across all age groups, and a small handful is orders of magnitude smaller than 10k. It does seem like a vaccine mandate even for under 40s is the smart thing to do.

That doesn’t even get into the benefit of preventing long Covid and being able to open the economy faster with fewer restrictions

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by briefcomment on Wednesday July 28, 2021 @06:17PM (#27990483)
And since we all know cholesterol and saturated fats are killers, we should ban butter and institute that everyone should have at least a tablespoon each of canola and sunflower oil a day. Except the science has now reversed to the point that polyunsaturated fats are being implicated as likely causes of obesity and metabolic disease.

You statement sounds far more confident than what the science would currently permit.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by Overton-Window on Wednesday July 28, 2021 @06:48PM (#27990749)
> You're forgetting the number 1 law of large numbers. Things that have a very low chance of probability happen all the time at scale.

Severe reactions to experimental vaccines for example?

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by gradys on Wednesday July 28, 2021 @03:48PM (#27988841)
On the last point:

1) The vaccine isn't perfect, and herd immunity nonlinearly reduces the risk of everyone including the vaccinated from getting it.

2) Unvaccinated people, who make up the vast majority of the cases, create an environment for the virus to evolve within, possibly mutating into a form that is more dangerous to everyone, including the vaccinated

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by incrudible on Wednesday July 28, 2021 @04:02PM (#27989005)
> The vaccine isn't perfect, and herd immunity nonlinearly reduces the risk of everyone including the vaccinated from getting it.

I would argue that the data now shows that herd immunity is not achievable with any vaccination rate. The vaccines just don't work that way, breakthrough infections are rampant.

> Unvaccinated people, who make up the vast majority of the cases, create an environment for the virus to evolve within, possibly mutating into a form that is more dangerous to everyone, including the vaccinated.

This is speculative. Vaccination-induced immunity is clearly not perfect, at the same it puts selection pressure on the virus. Natural immunity, going by reinfection rates, appears to be much stronger. I would speculate that in a population where 70% are vaccinated, where the amount of infections among the vaccinated is roughly the same, the virus is much more likely to mutate in the vaccinated individuals.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by sudosysgen on Wednesday July 28, 2021 @03:46PM (#27988820)
Only for you. The argument above was from civic responsibility, by being in crowded environments while unvaccinated you risk the lives of others.

Also, the chance of being disabled for a long while if you are young without comorbidity is far from 0%. It is quite significant, certainly above 0.5%.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by mrhands69 on Wednesday July 28, 2021 @03:49PM (#27988861)
What is the risk for people who are vaccinated? There should be some level of personal responsibility at this point. Everyone has had a chance to get the vaccine.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by estebank on Wednesday July 28, 2021 @03:58PM (#27988969)
Not everyone can take the vaccine. Which is why everyone that can, should, for everyone's sake.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by mrhands69 on Wednesday July 28, 2021 @04:08PM (#27989082)
What's the percentage of the population in the United States that can't get vaccinated for health reasons?
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by estebank on Wednesday July 28, 2021 @04:19PM (#27989210)
People with allergies and pregnant can get the vaccine for the most part, but because I can't find relevant numbers, lets say (incorrectly) that anyone with a food allergy can't get the vaccines: that'd be 32 million people (https://www.aafa.org/allergy-facts/).

~60 million are <12 years of age, which means that they aren't eligible for the vaccine at this time, and I've seen reports that it is unlikely we'll have vaccines for the youngest among us. So 82% of the population is the absolute most we can vaccinate.

With the demographic numbers and the (admittedly terrible proxy of) allergy numbers, 86 million people wouldn't be vaccinated (~25%). With a 0.2% percent fatality rate, we are talking about 170,000 deaths if all of them get infected.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by makomk on Wednesday July 28, 2021 @04:38PM (#27989397)
As I understand it, pretty much the only people who aren't eligible for vaccination in the US are those who've had an allergic reaction to a previous dose of the vaccine or one of its ingredients specifically and under-12s, though there are some additional observation requirements for people with a history of certain other allergic reactions. The former is quite a small group and children are at really low risk: https://news.sky.com/story/covid-19-only-0-005-of-covid-infe...
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by briefcomment on Wednesday July 28, 2021 @04:02PM (#27989015)
Ah yes, as soon as the world stops cultivating peanuts to accommodate my lethal (and heritable) peanut allergy. It should be a no brainer after all, with the nearly infinite other foods we have available as substitutes.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by estebank on Wednesday July 28, 2021 @04:09PM (#27989087)
Do you feel like prevalent labeling and stringent segregation policies in food handling to accommodate you aren't equivalent? And if someone's dish sends you into anaphylaxis at a dinner party, the host won't be going "Shouldn't have come then! I refuse to live in peanut-fear!".
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by swader999 on Wednesday July 28, 2021 @04:42PM (#27989453)
A reasonable court would put duty on the guest to inform the host of known allergies.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by joshuamorton on Wednesday July 28, 2021 @03:47PM (#27988829)
There are some people for whom the vaccine will not be effective (those who are already immunocompromised for example, or people with certain allergies to vaccine ingredients).

> But for a young person with no co-morbidities, that chance is still basically 0%.

Having long term side effects doesn't round to zero, even for young healthy people. And vaccine side effects do.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by makomk on Wednesday July 28, 2021 @03:57PM (#27988961)
Historically speaking, countries have refrained from forcing even medical workers and people caring for the elderly to get flu vaccines, even though this argument - that there are some people for whom the vaccine will not be effective - is even more true of that (in fact, as I understand it some studies suggest the flu vaccine might be basically ineffective at preventing serious complications and death in those at risk of them, leaving its ability to stop people from being infected and spreading it as the only way to reduce risk). As far as I can tell, the only reason to treat Covid differently basically boils down to partisan politics...
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by sudosysgen on Wednesday July 28, 2021 @04:54PM (#27989575)
Of course not. Most countries have mandated vaccines for HCW.

The reason the flu vaccine isn't one of them is because it's not that effective to begin with and you have to take it every year. It's not effective enough to really stop an epidemic, so instead vaccinating patients is the main thrust instead of HCW, because the overall impact will be fairly low.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by mahogany on Wednesday July 28, 2021 @04:45PM (#27989482)
> As far as I can tell, the only reason to treat Covid differently basically boils down to partisan politics...

A difference is that COVID is much deadlier, no?

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by mrhands69 on Wednesday July 28, 2021 @03:51PM (#27988892)
People can essentially get "long-covid" from the vaccine. Unfortunately, people are afraid to talk about it for fear of being labeled an antivax-er.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by joshuamorton on Wednesday July 28, 2021 @03:54PM (#27988919)
You'll, of course, cite a source?

There aren't actually any virus particles in the mRNA vaccines, so there's no biological mechanism for that to happen.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by mrhands69 on Wednesday July 28, 2021 @04:06PM (#27989053)
I can get a source in a bit. IIRC it was the spike protein that causes some (still unknown) response from the human body. The mRNA vaccine elicit a response from the immune system to reproduce the spike protein.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by sudosysgen on Wednesday July 28, 2021 @04:56PM (#27989598)
We have no idea that the spike protein causes long covid. It's much more likely that damage from the viral infection and immune response is at least an equal cause.

Beyond that, the virus causes orders of magnitude more spike protein response, so even if that was true, which it probably isn't, then it is still very unlikely that the vaccine could cause long-covid.

Also, all vaccines introduce spike proteins in the body, not just mRNA vaccines.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by d_silin on Wednesday July 28, 2021 @08:45PM (#27991515)
Source for above:

https://www.sciencedaily.com/releases/2020/12/201217154046.h...

Relevant part "The spike proteins alone can cause brain fog". And vaccines do produce viral proteins as intended.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by joshuamorton on Wednesday July 28, 2021 @09:02PM (#27991617)
That claim isn't made or supported by the cited nature article (https://www.nature.com/articles/s41593-020-00771-8).

It appears to come from a researcher contacted by the site for the article. And it's probably true.

However, there's a few reasons to believe that "long" covid like symptoms wouldn't come from the spike protein alone:

1. As a parent mentioned, you generate a lot fewer proteins w/ the vaccine than the virus

2. IIUC, those proteins are more localized. The soreness with an initial injection is inflammation due to spike protein creation, and that's usually localized to the injection site. The proteins themselves are less likely to travel as widely as the virus.

3. The proteins don't last very long. They're gone after a few days. So long term symptoms wouldn't be due to a continued immune response. They might be due to inflammation that hasn't gone down, I guess, but that seems unlikely to last months.

And again, all of these will be worse with the virus than the vaccine. You'll have more spike proteins, for longer, over a larger part of your body, and also have a virus attacking you in addition to the immune response.

Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by sudosysgen on Wednesday July 28, 2021 @09:17PM (#27991720)
Another thing is that spike protein from the vaccine in the arm has a much tougher time getting to the brain than viruses in the nose/olfactory bulb. That's on top of less spike to begin with.
Re:Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln,... by incrudible on Wednesday July 28, 2021 @04:14PM (#27989143)
> Having long term side effects doesn't round to zero, even for young healthy people. And vaccine side effects do.

I'm hesitant to just accept this as a fact. Vaccinations can cause very strong immune reactions in young adults that would otherwise likely suffer mild or asymptomatic infections. There are many surveys that query for a basket of sometimes unspecific symptoms such as "fatigue" or "brain fog" as a follow-up of a COVID infection. I'm missing that volume of surveys in the follow-up for vaccinations.