Wow, that is fascinating. The reason I likely haven't come across it is that my interest/research with regards to dementia is sleep specific. I'll definitely be keeping my eyes open for more acetycoline in the further research I come across. Thanks for bringing that to my attention.
I see where you're coming from re: "over-active" brain, and so I'd question if they're equating "over-active" with "reduced sleep", and if there is a commonality there.
I'm not a neurologist, I come from a software engineering background. I've always had an interest in neurology, and got into the sleep-tech field because I've always been an insomniac and started learning more about sleep.
Yeah I listened to a podcast recently about sleep, and how 'sleep' medications such as Ambien are only a partial method of inducing sleep, more like inducing unconsciousness and thus it changes your sleep architecture and prevents you from entering the proper deep sleep cycles. Wouldn't be surprised that benedryll has a similar problem if you use it to help you sleep and not just as an anti-histamine that you stay awake throughout.
https://www.peak-human.com/post/dr-kirk-parsley-md-is-sleep-...
Are you saying the drug prevents slow wave oscillations?
The main reason for my whole position is that my wife's village believes people who have an 'over-active' brain get dementia, and can all name examples. They have nothing like benadryl there.