The context and interpretation is always shifting and different. The human condition is always the same. So much comes back to simple communication. Things people often struggle with that are required for honest communication: listening, empathy, vulnerability, patience. It isn't some great unsolved puzzle in most relationships. I have often found it only takes one side to start bridging the gap to start truly communicating. It is when both parties insist on being right and aggrieved and conceding nothing that estrangement happens. Of course there are many complex situations, mental illness, etc. It works the same way in business. Everything is so much easier when you can listen and empathize with people. Actually empathize, not just empathize with the goal of making a point or convincing someone of decision, etc.