PHRMA plays big in politics, 501c4 space etc.
They also are known for the revolving door which is hard to quantify, but surely it makes a big difference on regs. Look at the Purdue, they got the regulator responsible for approving the label to actually sit in a hotel room and help write their oxy label together...
Here's an article shows "in the US from 1999 to 2018, found that the pharmaceutical and health product industry spent $4.7 billion, an average of $233 million per year, on lobbying the US federal government; $414 million on contributions to presidential and congressional electoral candidates, national party committees, and outside spending groups; and $877 million on contributions to state candidates and committees."
"The Chamber [of Commerce] spent nearly $82 million on lobbying in 2020"
But generally in line with the list posted by the GP:
"Facebook and Amazon were the only companies in the top 10 spending list and spent nearly $19.7 million and more than $18.7 million on lobbying in 2020, respectively"
I too, am surprised as how little this is for these gigantic companies ($20M for FB? 1/1000th of their quarterly revenue?) and more generally, how little money this is... in comparison with the entire US government budget?
Sorry, this is probably all obvious? Just a bit.. sad?
[0] https://thehill.com/business-a-lobbying/536082-us-chamber-nu...
https://www.opensecrets.org/federal-lobbying/top-spenders