Re:The mechanisms of action of Ivermectin against SARS-CoV-2
by snypher on Tuesday June 15, 2021 @11:48AM
(#27517192)
Ivermectin isn't an antiviral drug, so why should we give it any more focus than the positive effects of exercise, diet, prayer or anything else?
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Re:The mechanisms of action of Ivermectin against SARS-CoV-2
by Khelavaster on Tuesday June 15, 2021 @12:56PM
(#27518149)
Ivermectin is absolutely an antiviral drug. It blocks cells' α/β nuclear import protein--also used by a great number of RNA-based viruses--while letting other nuclear import proteins function normally.
"The well-tolerated drug ivermectin may hold great potential for treatment of YFV [yellow fever virus] infections. Furthermore, structure-based optimization may result in analogues exerting potent activity against flaviviruses other than YFV." (2012)
Re:The mechanisms of action of Ivermectin against SARS-CoV-2
by nradov on Tuesday June 15, 2021 @11:58AM
(#27517337)
Many drugs impact multiple biochemical systems. It doesn't matter whether it was previously classified as an antiviral drug or not.
In principle any drug can potentially be used to treat any disease. The real questions are: is there a plausible mechanism of action, and is it safe and effective in clinical trials?
Diet and exercise are known to impact COVID-19. We can focus on multiple different treatments simultaneously.