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Re:Heart inflammation cases in young men higher than expecte... by Mountain_Skies on Thursday June 10, 2021 @04:21PM (#27465282)
Wonder if this will lead to an increase in pericarditis over the next couple of years. I had pericarditis when I was a teen. The explanation from the cardiologist, which probably was dumbed down for me, was that sometimes a foreign body like bacteria or a virus gets hidden in the lining of the heart and when it later gets exposed to the immune system, it causes the pericardium to get enflamed, which squeezes the heart. How long do spike proteins (SARS-CoV-2 or vaccine created) hang out if they make it to the heart? We probably don't know yet.
Re:Heart inflammation cases in young men higher than expecte... by EMM_386 on Thursday June 10, 2021 @05:08PM (#27465875)
> How long do spike proteins (SARS-CoV-2 or vaccine created) hang out if they make it to the heart?

As far as I understand it, the vaccine doesn't work like this. It tells your immune system "hey this is what a SARS-CoV-2 spike protein looks like, attack it if you see it".

So the vaccine wouldn't cause the heart damage, the vaccine does (intentionally) ramp up your immune system to learn about this new threat, which it will then attack. It doesn't bind to ACE2, it teaches your immune system to look for bad things that can.

If there is still Covid in your heart due to prior exposure, your immune system is going to go there to assist. This would cause inflammation, but intentionally. As you noted, this immune system response is correct behavior.

So that's a long way of saying the inflammation is from the virus, not the vaccine. That's why I was thinking this may only occur in vaccinated individuals who had prior exposure to Covid.

Re:Heart inflammation cases in young men higher than expecte... by sjg007 on Thursday June 10, 2021 @05:30PM (#27466107)
The covid spike protein binds ace2 so the immune response to bind the spike could bind ace2 as well. Normally this is mitigated by a self selection filter but it is not out of the question that you could develop an autoimmune response.
Re:Heart inflammation cases in young men higher than expecte... by nielsbot on Thursday June 10, 2021 @11:13PM (#27468881)
Would it? My naive guess is that the immune response is an anti-ACE2 match. So it would bind to COVID spike protein, not the ACE2 receptor.
Re:Heart inflammation cases in young men higher than expecte... by cma on Thursday June 10, 2021 @08:21PM (#27467789)
The spike protien binds to ace2 receptors, so the immune response may be more likely to bind to ACE2, which also binds to ace2 receptors, but that isn't a given because the part on the spile the immune response targets don't have to themselves match with parts of ACE2.
Re:Heart inflammation cases in young men higher than expecte... by loa_in_ on Thursday June 10, 2021 @05:32PM (#27466115)
There are two variants of the vaccine:

One is mRNA (?) variant that gets into your cells and makes them produce just the spike protein. This lets your immune system find this protein out and make antibodies.

The other contains instead a partially destroyed viruses which trains the immune system directly on all their parts - the shell, the spikes, etc.

I don't remember which company makes which kind but both are in production.

Re:Heart inflammation cases in young men higher than expecte... by AareyBaba on Thursday June 10, 2021 @06:41PM (#27466825)
Your insights are not entirely correct. There are more than two types of covid vaccines.

Coronavirus Vaccines - An Introduction by JAMA is a good starting point. https://www.youtube.com/watch?v=KMc3vL_MIeo

COVID-19 Vaccines goes into greater detail. https://www.youtube.com/watch?v=35Idb_lCU4o

Re:Heart inflammation cases in young men higher than expecte... by zoomablemind on Friday June 11, 2021 @12:17AM (#27469234)
Chinese vaccine (SinoVac, CoronaVac) uses an inactivated whole SARS-CoV-2 virus.

https://www.medicalnewstoday.com/articles/covid-19-how-do-in...

"... In an inactivated vaccine, the pathogen is killed or modified in such a way that it is unable to replicate. It cannot cause disease and is, therefore, suitable for those with a compromised immune system.

The inactivation step usually involves heat, radiation, or chemicals to destroy the pathogen’s genetic material, which stops it from replicating.

Inactivated vaccines can trigger a strong immune reaction, but it is usually not as strong as the reaction that live attenuated vaccines can produce. Due to this, a person may need booster shots to ensure ongoing protection.

The COVID-19 vaccines that Sinovac, Sinopharm, and Bharat Biotech have developed are inactivated vaccines. ..."

Re:Heart inflammation cases in young men higher than expecte... by abracadaniel on Thursday June 10, 2021 @05:54PM (#27466305)
The mRNA vaccines don't produce the entire spike protein, just a portion of it in order to target the antibodies towards that specific portion of the spike.
Re:Heart inflammation cases in young men higher than expecte... by nielsbot on Thursday June 10, 2021 @11:35PM (#27468996)
How much of the spike protein is coded for?
Re:Heart inflammation cases in young men higher than expecte... by mike_hearn on Monday June 14, 2021 @05:31AM (#27500771)
Almost all of it except the part where it joins to the rest of the virus, where it's been modified to give it structural stability and stop it collapsing.
Re:Heart inflammation cases in young men higher than expecte... by rolph on Thursday June 10, 2021 @11:20PM (#27468917)
the "partially destroyed" virus is not a covid virus.

example the johnson&johnson vaccine [a vector vaccine] is composed of attenuated [part destroyed] human adenovirus [thus non reproductive] that has an insert of conformationaly stabilized spike sequence. this makes ease of shipping and handling, but lacks good efficacy if you are immune to the adenovirus

Re:Heart inflammation cases in young men higher than expecte... by Gibbon1 on Thursday June 10, 2021 @11:35PM (#27468990)
I think the J&J vaccine uses an adenovirus that can't reproduce in human cells. It's missing something or other it need to reproduce and only grows in a specialized cell culture.
Re:Heart inflammation cases in young men higher than expecte... by rolph on Thursday June 10, 2021 @11:43PM (#27469047)
yes you have it right.