News for hackers. Stuff that matters.
Re:Heart inflammation cases in young men higher than expecte... by lame-robot-hoax on Thursday June 10, 2021 @02:57PM (#27464226)
Yes, but the route in which a vaccination takes place (IM injection into deltoid) should mean that much much less of the spike protein ends up in the heart and lungs vs a natural infection. As well, the overall amount of spike protein in the body will be less.

https://blogs.sciencemag.org/pipeline/archives/2021/05/04/sp...

“Consider what happens when you’re infected by the actual coronavirus. We know now that the huge majority of such infections are spread by inhalation of virus-laden droplets from other infected people, so the route of administration is via the nose and/or lungs, and the cells lining your airway are thus the first ones to get infected. The viral infection process leads at the end to lysis of the the host cell and subsequent dumping of a load of new viral particles – and these get dumped into the cellular neighborhood and into the bloodstream. They then have a clear shot at the endothelial cells lining the airway vasculature, which are the very focus of these two new papers.

Compare this, though, to what happens in vaccination. The injection is intramuscular, not into the bloodstream. That’s why a muscle like the deltoid is preferred, because it’s a good target of thicker muscle tissue without any easily hit veins or arteries at the site of injection. The big surface vein in that region is the cephalic vein, and it’s down along where the deltoid and pectoral muscles meet, not high up in the shoulder. In earlier animal model studies of mRNA vaccines, such administration was clearly preferred over a straight i.v. injection; the effects were much stronger. So the muscle cells around the injection are hit by the vaccine (whether mRNA-containing lipid nanoparticles or adenovirus vectors) while a good portion of the remaining dose is in the intercellular fluid and thus drains through the lymphatic system, not the bloodstream. That’s what you want, since the lymph nodes are a major site of immune response. The draining lymph nodes for the deltoid are going to be the deltoid/pectoral ones where those two muscles meet, and the larger axillary lymph nodes down in the armpit on that side.”

Re:Heart inflammation cases in young men higher than expecte... by motohagiography on Thursday June 10, 2021 @04:17PM (#27465241)
Does that imply that the difference in hitting a vein with the injection vs. staying intramuscular would be where in the body the protein travels to and causes an immune response?

Nothing is ever that simple, but of cases with effects consistent with the protein being in the blood stream with consequences to the heart and brain, if that were a factor, it would be both testable and avoidable, and provide the explanation people would need to choose to get the shot. If the odds of accidentally hitting a vein and the bloodstream consequences as described lined up, it could move the issue forward.

I have zero expertise in this area, my interest in asking is what would make a more compelling case for getting more people immune, and having a straightforward explanation for the causes of the prior reports of harm would go a long way toward that goal.

Put another way: would injecting directly into an artery or vein have risks that the intramuscular jab would not - and do those risks resemble the anecdotal reports of myo, clots, and deaths?

Re:Heart inflammation cases in young men higher than expecte... by T-A on Thursday June 10, 2021 @05:39PM (#27466184)
It's been hypothesized that AstraZeneca's vaccine is more likely to cause clots when accidentally injected intravenously:

https://www.sortiraparis.com/news/coronavirus/articles/24662...

Re:Heart inflammation cases in young men higher than expecte... by nikolay on Saturday June 12, 2021 @05:08AM (#27482947)
The adenoviruses already attach to red blood cells and have the blood clotting issue with or without the extra genetic load they carry in the COVID-19 vaccine case. It's been known of over a decade and I wonder why no precautions are prescribed before and after the shots.
Re:Heart inflammation cases in young men higher than expecte... by rolph on Thursday June 10, 2021 @05:16PM (#27465971)
expect immediate and catastrophic thromboembolism upon IV administration of any current covid vaccine none of them are formulated for IV administration

https://portal.ct.gov/-/media/Coronavirus/Community_Resource...

Re:Heart inflammation cases in young men higher than expecte... by SamBam on Thursday June 10, 2021 @03:14PM (#27464420)
> As well, the overall amount of spike protein in the body will be less.

Less that an acute infection, probably.

Less than a mild asymptomatic infection? Do we know that? My understanding was that they packed quite a lot of mRNA into the shot in order to ensure a response.

Re:Heart inflammation cases in young men higher than expecte... by officialjunk on Thursday June 10, 2021 @03:51PM (#27464914)
infection is a spectrum, sure, but the public usage of the word "asymptomatic" does not include cardiovascular side effects, that can show up some weeks/months later.

we are observing "asymptomatic" infections followed by cardiovascular problems for some. is it really asymptomatic in those cases?

Re:Heart inflammation cases in young men higher than expecte... by newsclues on Thursday June 10, 2021 @03:09PM (#27464367)
“Should”

Has it been tested?

Re:Heart inflammation cases in young men higher than expecte... by VoiceOfWisdom on Thursday June 10, 2021 @03:21PM (#27464504)
Its in testing right now.
Re:Heart inflammation cases in young men higher than expecte... by newsclues on Thursday June 10, 2021 @03:28PM (#27464592)
I’m listening to the livestream on Bret Weinstein’s channel and they are discussing data that states the opposite including data that shows a concentration in the ovaries.
Re:Heart inflammation cases in young men higher than expecte... by 0-_-0 on Thursday June 10, 2021 @06:06PM (#27466430)
I'm listening to the same podcast. The source was Pfizer data obtained via FOIA request, it was a Japanese study I think.

edit: this one: https://files.catbox.moe/0vwcmj.pdf

Here's the data in a plot:

https://trialsitenews.com/wp-content/uploads/2021/06/Ovaries...

Re:Heart inflammation cases in young men higher than expecte... by jimmyswimmy on Thursday June 10, 2021 @09:24PM (#27468282)
At first glance that plot made me curious, but if you look at the raw data in the pdf, you can clearly see that whoever made the plot was trying to scare people.

They correctly plotted the total lipid concentration for a lot of things, including the ovaries (which stand out on the plot) but completely ignored the injection site (which might be reasonable, but gives a sense of scale), the adrenal glands (which have around the same content as the ovaries), liver (roughly double ), the spleen (a bit more than double).

I'm having a difficult time taking these omissions as anything other than an attempt to spread fear. As a non-expert in biology it seems reasonable that a lot of an injection into my body should ultimately end up in my liver and spleen. The attempt to obscure this probably-natural result (and instead focus on ovaries) is strange.

Re:Heart inflammation cases in young men higher than expecte... by lame-robot-hoax on Thursday June 10, 2021 @04:08PM (#27465143)
I’d be interested to see a source. I know of rat models that show a very small accumulation in ovaries, but these rats were afaik given doses in the range of 300x-1000x that of a human. And the accumulation in the ovaries or other regions was still incredibly small, despite the dosage given.
Re:Heart inflammation cases in young men higher than expecte... by lootsauce on Thursday June 10, 2021 @04:19PM (#27465268)
Re:Heart inflammation cases in young men higher than expecte... by dekken_ on Thursday June 10, 2021 @04:52PM (#27465669)
Re:Heart inflammation cases in young men higher than expecte... by 0-_-0 on Thursday June 10, 2021 @06:06PM (#27466434)
This is the one
Re:Heart inflammation cases in young men higher than expecte... by osipov on Thursday June 10, 2021 @03:08PM (#27464347)
>The injection is intramuscular, not into the bloodstream.

Recent research (per No Agenda shownotes) showed that unlike traditional vaccines, Moderna mRNA spread through the bloodstream producing and distributing spike protein in the entire body.

Re:Heart inflammation cases in young men higher than expecte... by lame-robot-hoax on Thursday June 10, 2021 @04:12PM (#27465188)
What do you mean by “spread through the bloodstream”?

Of course even in an IM injection, some will end up in the blood stream. The better question is the overall amount that stays within the deltoid vs that that travels elsewhere, and how the compares to natural infection. How does the virus deposit itself around the body vs. how does the spike protein via vaccination deposit itself around the body. As well, with the way the vaccine works, once it hits a cell, that cell will express the spike protein to the surface and that’s it, instead of contributing to further viral spread in the same region.