The F150 has fuel economy close to that of wagons sold in the US. The F150 is less efficient, but it has way more than half the fuel economy of a wagon. Examples:
A base E-Class Wagon gets 24 mpg (22 city, 28 highway). A 4WD V6 F150 (which I think is the most popular) gets 21 mpg (19 city, 24 highway). The most efficient F150 available (the 2WD Hybrid) gets 25 mpg (25 city, 26 highway).
Wagons aren't super popular in the US so there aren't that many on the market. Here is a comparison of the fuel economies of the F150 vs several wagons available in the US: https://www.fueleconomy.gov/feg/Find.do?action=sbs&id=43464&...
Of course the E450 is going to get atrocious mileage, it’s a V6 turbocharged luxury car
It’s crazy that the choice is so limited in the US. I can understand why the Prius was so popular with you guys, despite handling like a whale on wheels.. there are nearly no options in the big hatchback segment .