What's also fatiguing: searching for something e.g. for work and then getting distracted by ads.
Also, companies tune their algorithms such that they get maximum income from ads.
Therefore, I bet that ditching ads would solve 90% of the problems.
To the contrary, the main thing that wears me out is interacting with AI systems which change from an interaction to another and aren't predictable - text completion on mobile, search results on datasets, order of posts on forums, etc etc. If I use a computer it's because it (used to) be predictable and dumb : I do action A, I get reaction B. With AI systems, if I do action A twice I generally get a different B for whatever unknown reason there is, and that makes me want to throw the device out by the window out of frustration.