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A comment on SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2. Parent comment

Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by busyant on Sunday May 02, 2021 @11:45AM (#27016224)
This is a legitimate question, so I don't know why it's being downvoted. Especially given the statement in the abstract of the paper that says, "We show here that S protein alone can damage vascular endothelial cells (ECs) in vitro and in vivo...."

That being said, other people on this thread have provided reasonable mechanistic explanations as to why the vaccines would not have this effect, but I will also add we have _empirical_ evidence that the vaccine does not impair endothelial function (or at least it is extremely rare) because we have millions of people who have received the vaccine without impaired endothelial function.

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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by dcow on Sunday May 02, 2021 @01:00PM (#27016786)
My partner developed inflammation (resembling gottron papules) on her knuckles a few weeks after receiving the first moderna dose. She now (few days later) has developed a shoulder rash where the vaccine was injected. It’s very curious.
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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by lc9er on Sunday May 02, 2021 @01:13PM (#27016902)
My spouse, who suffers from an autoimmune disorder, suffered similar symptoms. Severe enough that she won’t be able to get the second dose. My understanding (from her doc) is that this is a known, but uncommon side effect for people with autoimmune conditions.
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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by podgaj on Sunday May 02, 2021 @04:07PM (#27018550)
Just sayin’

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793296/

The data presented in our work, although very heterogeneous in the manner of collecting and investigating samples, have proved to be extremely consistent in witnessing a deficiency of zinc in serum and plasma of patients compared to controls.

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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by treeman79 on Sunday May 02, 2021 @02:24PM (#27017541)
Does get the uncommon side effects of medication much?

Have an autoimmune, and I get most of the rare side effects of medications.

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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by lc9er on Sunday May 02, 2021 @03:02PM (#27017895)
Constantly. Her list of banned medications is huge. Each time she’s prescribed a medication, she has to decide if the “rare side effects” are worth risking or are worse than going untreated.
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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by IAmGraydon on Sunday May 02, 2021 @04:13PM (#27018608)
Someone I work with (female, 25 years old) had inflammation on her knuckles that is similar to what you describe. This was after her second shot - not sure if it was Moderna or Pfizer, but it was MRNA. She's fine and it eventually went away, but it's certainly interesting. She doesn't have any autoimmune disorders that she knows of.
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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by Gibbon1 on Sunday May 02, 2021 @04:45PM (#27018847)
The vaccine appeared to piss off the RSI in my right arm for about two weeks. I would have gotten the shot in my left arm if I knew that was going to happen.
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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by christkv on Sunday May 02, 2021 @04:17PM (#27018645)
I've also not seen any studies about side effects in people who already had the virus before getting the first dose.
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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by sebmellen on Sunday May 02, 2021 @01:13PM (#27016908)
Quite strange. I've had almost the exact same skin-level reactions, only I received the BioNTech/Pfizer vaccine.
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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by sroussey on Sunday May 02, 2021 @01:43PM (#27017161)
I had a red area after the second shot on my shoulder, and so did my family members including cousins in other states.
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