1) Sites with multi-column or table design that can show more information when the browser window is wide. I tend to widen the browser window to get the most out of these pages.
2) Sites like Daring Fireball that have a fixed width, so I can still read the content just fine whether or not the window is wide.
3) Sites that expand the line length to wrap at whatever width the browser is at. I find these impossible to read unless I narrow the browser window because I lose track of which line of text I’m reading.
Types (1) and (2) are compatible and make up the large majority of sites I visit. Type (3) isn’t compatible for me, so I find it inconvenient. It’s not the end of the world, but it slightly inhibits my desire to visit such pages. I’d rather not maintain a multi-level navigation hierarchy with multiple windows and multiple tabs in a window.
Ecommerce sites are a minefield.
Saas and anything table-y or app-y, you're also out of luck for the most part.
I'll still take it over Paul Graham's blog with all the text way over there on the left edge.