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A comment on mRNA vaccines – a new era in vaccinology (2018). Parent comment

Re:mRNA vaccines – a new era in vaccinology (2018) by colinmcd on Tuesday April 20, 2021 @01:22PM (#26877578)
I'm no biologist, but mRNA is ephemeral by design - it's constantly being broken down in the body. The fact that mRNA is converted to proteins by ribosomes is one of the best understood processes in cellular biology, and synthesizing the mRNA for a new protein is not a new idea. Getting actual viral vectors injected into my arm seems much more concerning on the surface (though it's obviously also very safe).
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Re:mRNA vaccines – a new era in vaccinology (2018) by yasp on Tuesday April 20, 2021 @02:02PM (#26878257)
Were that it was so simple. My understanding is the mRNA used in the vaccines was engineered to be more stable (less ephemeral). Not sure what that means in terms of half life, but AFAICT it's a mistake to assume that it will behave similarly to naturally occurring mRNA if this is true.
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Re:mRNA vaccines – a new era in vaccinology (2018) by pkaye on Tuesday April 20, 2021 @02:21PM (#26878714)
They put a lipid coating around the mRNA to protect it. But as soon as that coating is removed, it will be quickly be broken down in the body by various enzymes.
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Re:mRNA vaccines – a new era in vaccinology (2018) by yasp on Tuesday April 20, 2021 @03:08PM (#26879770)
How long does the coating take to be removed? Can the mRNA still be (reverse-)transcribed while in the presence of this coating?
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Re:mRNA vaccines – a new era in vaccinology (2018) by pkaye on Tuesday April 20, 2021 @03:24PM (#26880058)
I'm no expert on this but the lipid coating allows it to enter the cell where the coating is removed and the reverse transcription happens. I've read that any of the mRNA that is injected will be gone within 2-3 in the body.
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Re:mRNA vaccines – a new era in vaccinology (2018) by primozk on Wednesday April 21, 2021 @03:09AM (#26886314)
2-3 what?
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Re:mRNA vaccines – a new era in vaccinology (2018) by pkaye on Wednesday April 21, 2021 @04:55PM (#26895331)
days
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Re:mRNA vaccines – a new era in vaccinology (2018) by kolinko on Wednesday April 21, 2021 @04:11AM (#26886694)
If it can be reverse transcribed then so can Covid which has the same mRNA as the vaccine and way way more. Plus, covid infects a million times more cells than the mRNA vaccine.
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Re:mRNA vaccines – a new era in vaccinology (2018) by lima on Wednesday April 21, 2021 @08:44AM (#26888895)
But they also modified the mRNA structure to make it more durable (but still on the order of days/weeks).
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