mRNA vaccines – a new era in vaccinology (2018)

Re:mRNA vaccines – a new era in vaccinology (2018) by pkaye on Tuesday April 20, 2021 @02:21PM (#26878714)

They put a lipid coating around the mRNA to protect it. But as soon as that coating is removed, it will be quickly be broken down in the body by various enzymes.

[ Parent | on HN ]

Re:mRNA vaccines – a new era in vaccinology (2018) by yasp on Tuesday April 20, 2021 @03:08PM (#26879770)

How long does the coating take to be removed? Can the mRNA still be (reverse-)transcribed while in the presence of this coating?

[ Parent | on HN ]

Re:mRNA vaccines – a new era in vaccinology (2018) by pkaye on Tuesday April 20, 2021 @03:24PM (#26880058)

I'm no expert on this but the lipid coating allows it to enter the cell where the coating is removed and the reverse transcription happens. I've read that any of the mRNA that is injected will be gone within 2-3 in the body.

[ Parent | on HN ]

Re:mRNA vaccines – a new era in vaccinology (2018) by primozk on Wednesday April 21, 2021 @03:09AM (#26886314)

2-3 what?

[ Parent | on HN ]

Re:mRNA vaccines – a new era in vaccinology (2018) by pkaye on Wednesday April 21, 2021 @04:55PM (#26895331)

days

[ Parent | on HN ]

Re:mRNA vaccines – a new era in vaccinology (2018) by kolinko on Wednesday April 21, 2021 @04:11AM (#26886694)

If it can be reverse transcribed then so can Covid which has the same mRNA as the vaccine and way way more. Plus, covid infects a million times more cells than the mRNA vaccine.

[ Parent | on HN ]

Re:mRNA vaccines – a new era in vaccinology (2018) by lima on Wednesday April 21, 2021 @08:44AM (#26888895)

But they also modified the mRNA structure to make it more durable (but still on the order of days/weeks).

[ Parent | on HN ]