I'd argue the tuning of the guitar makes it remarkably ergonomic and flexible. Guitar players take it for granted how you can play the same chord all up and down the neck. If a shape is clumsy for you, there are many others you can try to get the same chord, but I think the shapes in general are designed pretty well for the hand once you develop your finger muscles and flexibility. There is a lot of logic baked into the guitar's fretboard layout.