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A comment on The EMA Covid-19 data leak, and what it tells us about mRNA instability. Parent comment

Re:The EMA Covid-19 data leak, and what it tells us about mR... by et2o on Tuesday March 16, 2021 @04:29PM (#26482451)
Encode smaller bits of the same protein? Who cares.

Otherwise, the mRNAs aren’t present in high enough quantities to do significant signaling or silencing things, and it’s going in the deltoid... not really a medically interesting place. You could inject 1mL of dilute HCl there and it wouldn’t be a big problem.

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Re:The EMA Covid-19 data leak, and what it tells us about mR... by ppf on Tuesday March 16, 2021 @04:43PM (#26482668)
I'd rather not be injected with bits of mRNA that encode random bits of proteins, thanks. The deltoid is "medically interesting" enough to produce Covid spike proteins.
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Re:The EMA Covid-19 data leak, and what it tells us about mR... by timy2shoes on Tuesday March 16, 2021 @04:53PM (#26482817)
Won't non-intact mRNA without a stop codon get degraded by Non-stop decay?
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Re:The EMA Covid-19 data leak, and what it tells us about mR... by rolph on Tuesday March 16, 2021 @05:30PM (#26483294)
you have the idea right , but it isnt a stop codon its a signal sequence on the mRNA that would give it a hall pass.

no cytoplasmic nucleotide transport signal and it gets degraded quickly.

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Re:The EMA Covid-19 data leak, and what it tells us about mR... by et2o on Wednesday March 17, 2021 @11:00PM (#26499327)
Don’t get the vaccine then, because you are getting small pieces of mRNA.
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Re:The EMA Covid-19 data leak, and what it tells us about mR... by Tossitto on Tuesday March 16, 2021 @06:44PM (#26484203)
Proteopathy is a real thing. Prion dysfunctions can cause self-replication, not that the makeup is necessarily there for that in these vaccines. Interesting starting point for consideration nonetheless.
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