Re:The EMA Covid-19 data leak, and what it tells us about mR...
by ppf on Tuesday March 16, 2021 @04:19PM
(#26482281)
It's not the percentage of intact mRNA that's the problem, it's what the other bits of mRNA happen to do.
[ Parent
| on HN ]
Re:The EMA Covid-19 data leak, and what it tells us about mR...
by topynate on Tuesday March 16, 2021 @05:35PM
(#26483365)
Didn't I cover that in "danger"? The leaks are talking about maybe twice as much broken bits of mRNA in early batches. That's assuming all the not-intact stuff is broken mRNA rather than simple amino acids or something else just as boring. That shouldn't make much difference to anyone's view. If you think it's "doing" stuff that makes you not want to get vaccinated, well you probably thought that before you read this report, too.
Re:The EMA Covid-19 data leak, and what it tells us about mR...
by cfu28 on Tuesday March 16, 2021 @05:12PM
(#26483041)
Anything particular reason you're worried about extra mRNA fragments? mRNA needs a initiation sequence in order to be translated into a protein, which only exists at the front. It also needs a polyA tail to maintain stability or it would just degrade. Random fragments don't do anything on their own
Re:The EMA Covid-19 data leak, and what it tells us about mR...
by et2o on Tuesday March 16, 2021 @04:29PM
(#26482451)
Encode smaller bits of the same protein? Who cares.
Otherwise, the mRNAs aren’t present in high enough quantities to do significant signaling or silencing things, and it’s going in the deltoid... not really a medically interesting place. You could inject 1mL of dilute HCl there and it wouldn’t be a big problem.
Re:The EMA Covid-19 data leak, and what it tells us about mR...
by ppf on Tuesday March 16, 2021 @04:43PM
(#26482668)
I'd rather not be injected with bits of mRNA that encode random bits of proteins, thanks. The deltoid is "medically interesting" enough to produce Covid spike proteins.
Re:The EMA Covid-19 data leak, and what it tells us about mR...
by timy2shoes on Tuesday March 16, 2021 @04:53PM
(#26482817)
Won't non-intact mRNA without a stop codon get degraded by Non-stop decay?
Re:The EMA Covid-19 data leak, and what it tells us about mR...
by rolph on Tuesday March 16, 2021 @05:30PM
(#26483294)
you have the idea right , but it isnt a stop codon its a signal sequence on the mRNA that would give it a hall pass.
no cytoplasmic nucleotide transport signal and it gets degraded quickly.
Re:The EMA Covid-19 data leak, and what it tells us about mR...
by et2o on Wednesday March 17, 2021 @11:00PM
(#26499327)
Don’t get the vaccine then, because you are getting small pieces of mRNA.
Re:The EMA Covid-19 data leak, and what it tells us about mR...
by Tossitto on Tuesday March 16, 2021 @06:44PM
(#26484203)
Proteopathy is a real thing. Prion dysfunctions can cause self-replication, not that the makeup is necessarily there for that in these vaccines. Interesting starting point for consideration nonetheless.
Re:The EMA Covid-19 data leak, and what it tells us about mR...
by rolph on Tuesday March 16, 2021 @05:27PM
(#26483242)
these fragments of mRNA will be recognized as antigens, until the point that the folded structure of the epitopes is destroyed, these smaller fragments are still recognized as viral PAMPs and evoke innate immune responses.