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A comment on Moderna Covid vaccine candidate almost 95% effective, trials show. Parent comment

Re:Moderna Covid vaccine candidate almost 95% effective, tri... by dystroy on Monday November 16, 2020 @08:41AM (#25111469)
Isn't the difference more due to tests levels and announcement precautions ? Pfizer's announced temperature looks like the one for very long term ARN storage while standard fridge for a month doesn't look like it should alter ARN much.

I'm not sure there's a real difference here.

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Re:Moderna Covid vaccine candidate almost 95% effective, tri... by mercurywells on Monday November 16, 2020 @08:53AM (#25111593)
Pfizer's can actually be stored for 5 days at normal fridge temperatures after removing it from deep-cold storage.
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Re:Moderna Covid vaccine candidate almost 95% effective, tri... by thehappypm on Monday November 16, 2020 @12:56PM (#25114797)
I read in the New York Times article that Moderna and Pfizer use different (proprietary) lipid solutions in the vaccines. It's possible that Pfizer is just being overly cautious and they don't need the ultra cold storage, but it's also possible that Moderna has a fundamentally better solution.
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Re:Moderna Covid vaccine candidate almost 95% effective, tri... by abacadaba on Monday November 16, 2020 @08:51AM (#25111578)
Anyone know the difference in delivery mechanism between these two? Both are mRNA right?
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Re:Moderna Covid vaccine candidate almost 95% effective, tri... by aphextron on Monday November 16, 2020 @09:30AM (#25112020)
>Anyone know the difference in delivery mechanism between these two? Both are mRNA right?

They're extremely similar. Both are mRNA delivered via lipid nanoparticle vector.

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Re:Moderna Covid vaccine candidate almost 95% effective, tri... by dnautics on Monday November 16, 2020 @04:53PM (#25117454)
Who knows. Almost all therapeutic rnas have unnatural RNA bases or base linkages that are, for example, resistant to internal phosphatases/autohydrolysis to improve half life; half life can also depend on secondary structure, and of course as a sibling comment mentioned, it can depend on the stability of the lipid nanoparticles.
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