News for hackers. Stuff that matters.

A comment on Moderna Covid vaccine candidate almost 95% effective, trials show. Parent comment

Re:Moderna Covid vaccine candidate almost 95% effective, tri... by abacadaba on Monday November 16, 2020 @08:51AM (#25111578)
Anyone know the difference in delivery mechanism between these two? Both are mRNA right?
[ Parent | on HN ]
Re:Moderna Covid vaccine candidate almost 95% effective, tri... by aphextron on Monday November 16, 2020 @09:30AM (#25112020)
>Anyone know the difference in delivery mechanism between these two? Both are mRNA right?

They're extremely similar. Both are mRNA delivered via lipid nanoparticle vector.

[ Parent | on HN ]
Re:Moderna Covid vaccine candidate almost 95% effective, tri... by dnautics on Monday November 16, 2020 @04:53PM (#25117454)
Who knows. Almost all therapeutic rnas have unnatural RNA bases or base linkages that are, for example, resistant to internal phosphatases/autohydrolysis to improve half life; half life can also depend on secondary structure, and of course as a sibling comment mentioned, it can depend on the stability of the lipid nanoparticles.
[ Parent | on HN ]