Last time I tried it, and I heard that's still the case, offlineimap had some sporadic instabilities that have not been fixed for years. I don't remember the exact details, but it just stops working in some situations and you have to restart it.

isync/mbsync are rock-solid on the other hand and were really easy to set up.

I find that isync is much faster, and much more reliable. Offlineimap would often run out of memory, or silently fail dozens of times in a row.

I've not seen it OOM, but I have 64GB of ram.

isync doesn’t let the fan of my laptop cpu run. Yes, no joke, I could detect the running of offlineimap by the fan.