Obviously niche, but most amusing. Imagine a 48-core 5 GHz MacPro G5.
That said I love the idea from the perspective of a wonderful hack, but I truly hope no one actually has a use case where running classic Mac OS on modern hardware makes sense.
It had the first implementation of the multiprocessing unit, and lacked the load/store and registry units of all the later processors.
The PowerPC 601 is functionally quite similar to modern 32 bit PowerPC.
Or should we call the Z80 a 16 bit processor?
Z80 is classified as an 8-bit processor because it has an 8-bit internal data bus to the register file.⁽¹⁾
This is visible in instruction timings: 16-bit INC BC takes longer than 8-bit INC B because the 16-bit register access takes two internal data cycles compared with one internal cycle for 8-bit.
Intel 8086 is classified as a 16-bit processor because it has a 16-bit internal data bus to the register file.
This is visible in instruction timings: 16-bit register operations generally take the same time as 8-bit register operations.⁽²⁾
⁽¹⁾ Trivia: Z80 also has a 16-bit internal address bus and 4-bit ALU.
⁽²⁾ Actually 8-bit INC AL takes longer than 16-bit INC AX, opposite way around from Z80. But that's because of a longer instruction encoding, not architecture. MOV AL,BL takes the same time as MOV AX,BX.)
I imagine they extended the ISA to 64 bits and maybe that was an opportunity for further ISA changes?