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A comment on Study finds people have short-lived immunity to seasonal coronaviruses.

Re:Study finds people have short-lived immunity to seasonal ... by Symmetry on Tuesday September 29, 2020 @11:06AM (#24628695)
It's important to distinguish between sterilizing immunity and protective immunity here. It's pretty common to get re-infected relatively quickly by a Coronavirus but previous studies showing the same thing also showed that these re-infections didn't cause disease, that is symptoms. And since transmissibility is generally correlated with intensity of symptoms there's reason to believe that vaccination still helps with that, though not as much as we would hope.

And our few examples of known re-infections with SARS-2 don't seem to have caused disease the second time around.

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Re:Study finds people have short-lived immunity to seasonal ... by jdavis703 on Tuesday September 29, 2020 @11:41AM (#24629165)
> And since transmissibility is generally correlated with intensity of symptoms

Is asymptomatic and pre-symptomatic transmission no longer thought of as a significant transmission route anymore?

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Re:Study finds people have short-lived immunity to seasonal ... by Symmetry on Tuesday September 29, 2020 @11:51AM (#24629306)
Sorry, correlated with the maximum intensity of symptoms over the course of the disease. Your viral load peaks right before you develop symptoms (generally). But viral load at peak tends to predict the severity of later symptoms and so being long-term asymptomatic is correlated with lower peak viral load. Plus, in addition to viral load, some symptoms like coughing increase transmissibility.

EDIT: I'm not saying that a vaccine that conveys protective but not sterilizing immunity means we can stop worrying about true asymptomatic transmission entirely. But I'd assume that it's enough to driver the natural R0 well below 1.0 if everyone gets the vaccine all by itself.

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Re:Study finds people have short-lived immunity to seasonal ... by addicted on Tuesday September 29, 2020 @12:26PM (#24629795)
With COVID-19 there are 2 confirmed cases of reinfection. 1 of them did not have symptoms on reinfection but the other did.
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Re:Study finds people have short-lived immunity to seasonal ... by thehappypm on Tuesday September 29, 2020 @01:32PM (#24630624)
Out of tens of millions of cases, we have had 2 reinfections, one of whom had symptoms. To me that is very very strong evidence that reinfection is not a factor.
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