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Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by bildung on Friday September 25, 2020 @09:37AM (#24589553)
Here is one, took me about half a minute to find: https://www.nature.com/articles/s41591-020-0843-2

Counterquestion: Will presence of this evidence modify your position?

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by DanBC on Friday September 25, 2020 @10:09AM (#24589866)
Parent asked for evidence that mass mask wearing prevent the spread of the disease. You presented a study that shows some masks if worn properly block some viruses.

Can you see how the study you presented doesn't answer parent post's question?

Further, your study tests the first breath exhalation.

> We screened 3,363 individuals in two study phases, ultimately enrolling 246 individuals who provided exhaled breath samples (Extended Data Fig. 1). Among these 246 participants, 122 (50%) participants were randomized to not wearing a face mask during the first exhaled breath collection and 124 (50%) participants were randomized to wearing a face mask. Overall, 49 (20%) voluntarily provided a second exhaled breath collection of the alternate type.

So, your test says "when you put on a mask that mask will, immediately after you put it on, stop your exhaled breath hitting a plate placed in front of your mouth".

It says nothing about how effective that mask is over time.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by username90 on Friday September 25, 2020 @01:35PM (#24592139)
Masks gets moist over time and virus will build up in it, are there any tests checking how well they work after a full workday? It wouldn't be strange if the virus buildup on the mask pretty quickly makes you start spreading covid, and then the false sense of security would actually cause them to increase spread rather than reduce it.

Edit: Also that is for surgical face masks, most people just put a piece of cloth in their face. I would like to see a study for a piece of cloth in front of your mouth for the entire day and see how much virus there is after that.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tboyd47 on Friday September 25, 2020 @10:09AM (#24589864)
Thanks. That study doesn't measure any sort of disease spread. It measures the density of candle smoke on either side of the mask.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by bildung on Friday September 25, 2020 @11:04AM (#24590556)
Not at all, perhaps you meant another commenter? From the link "Before exhaled breath collection, each participant was randomly allocated in a 1:1 ratio to either wearing a surgical face mask (cat. no. 62356, Kimberly-Clark) or not during the collection. [...] Participants were then invited to provide a second exhaled breath sample of the alternate type (for example if the participant was first assigned to wearing a mask they would then provide a second sample without a mask)"

They actually tested infected patients with and without mask.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by dbsights on Friday September 25, 2020 @08:01PM (#24595271)
>We detected coronavirus in respiratory droplets and aerosols in 3 of 10 (30%) and 4 of 10 (40%) of the samples collected without face masks, respectively, but did not detect any virus in respiratory droplets or aerosols collected from participants wearing face masks, this difference was significant in aerosols and showed a trend toward reduced detection in respiratory droplets (Table 1b).

This study is incredibly small, and operating on the limits of significance. Its hardly conclusive, and was done under fairly extreme conditions (30 mins in close proximity) compared to the scenarios in which masks are mandated today. The authors even mention that, for those who did not cough, no detectable virus was identified regardless of whether a mask was worn. Considering that the point of mandatory masking is to prevent asymptomatic transmission from brief interactions with strangers, I just don't find this study very convincing as a scientific basis for a mask mandate.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by thakoppno on Friday September 25, 2020 @09:55AM (#24589703)
> Participants were recruited year-round from March 2013 through May 2016

The study you linked did not have any covid patients.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by adrianN on Friday September 25, 2020 @10:00AM (#24589763)
The question was

> slows the spread of COVID-19 or a similar respiratory disease

What makes you believe that COVID-19 is spread significantly differently that the inconvenience of having to wear a mask is not bearable relative to the potential benefits? Do you believe that masks have risks other than being inconvenient?

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by thakoppno on Friday September 25, 2020 @12:20PM (#24591423)
fwiw: my household’s being hyper-vigilant regarding covid, rarely doing anything beyond social distancing. i'm looking for a study that validates the conventional wisdom about masking so that we know we aren’t contributing to the spread. at no point am i suggesting any behavior that isn’t backed by scientific data.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by bildung on Friday September 25, 2020 @11:06AM (#24590573)
They did have coronavirus patients, though. I'm not aware of significant physical differences between Covid-19 and other coronaviruses.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by ahelwer on Friday September 25, 2020 @09:33AM (#24589497)
I've been down this road with a few people, so I'll take a shortcut and get to the crux of it: do you believe that masks stop spread of coronavirus between individuals? If so, what factor would account for masks stopping spread between individuals but not stopping spread over the population?
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by neilwilson on Friday September 25, 2020 @10:00AM (#24589751)
Not wearing it all the time. Not changing it in the recommended time period. Taking it off and putting it on backwards. Waving it around after taking it off rather than folding inwards and disposing in a sharps bag.

All the things that happen in daily life rather than in a medical setting. Which is why despite full mask protocols and sanitiser at the door to every classroom kids going back to school this week around here have all have gone down with viral sore throats and noses.

That shouldn’t have happened if masks do what it says on the tin.

Unfortunately network effects dominate. We are not hamsters living permanently in cages.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tboyd47 on Friday September 25, 2020 @10:41AM (#24590284)
The most compelling objection (to me) is that when surgeons wear masks, they sneeze inside their masks, then change their masks. When everyday people wear masks, we take our masks off to sneeze, expelling aerosol virus particles into the air to be circulated in the A/C for hours (probably days). That said, some studies have shown a small effect of mask mandates on daily case count growth.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by DanBC on Friday September 25, 2020 @10:13AM (#24589910)
> do you believe that masks stop spread of coronavirus between individuals?

We don't know, we don't have much evidence either way.

> but not stopping spread over the population?

Where do people wear masks? They wear masks when leaving their homes. Some of those journeys are essential, but a lot of them are not.

People have chosen something (mask wearing) that has at best weak evidence over something (physical distancing) that has much stronger evidence.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tzs on Friday September 25, 2020 @11:19AM (#24590712)
> People have chosen something (mask wearing) that has at best weak evidence over something (physical distancing) that has much stronger evidence.

Most recommendations I've seen are to do both.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by username90 on Friday September 25, 2020 @01:54PM (#24592355)
Many people don't do both though, when they have masks they do this:

https://www.stripes.com/polopoly_fs/1.635444.1593270228!/ima...

They might have done so even without masks, it is hard to say, but it is pretty easy for people to think that it is fine to not keep distance when they have masks.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tboyd47 on Friday September 25, 2020 @09:35AM (#24589523)
I don't know if it does or doesn't, because I've never seen any scientific studies on universal mask mandates. That's why I'm asking.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by Voloskaya on Friday September 25, 2020 @09:40AM (#24589574)
Finding one of those studies would have taken you way less time that typing your comment. So I think we can all safely assume you are not asking this question in good faith, and you wouldn't believe one such study anyway.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tboyd47 on Friday September 25, 2020 @10:23AM (#24590059)
For your information, I was asking to expand my own knowledge on the subject. Top level commenter was adamant that masks were effective, so this being HN, where people typically know what they're talking about, I assumed they had a good reason to think that way. I have researched this a great deal myself, and have not found anything except flawed or inconclusive studies, like the majority of links submitted in this thread. Have a great day.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by DanBC on Friday September 25, 2020 @10:18AM (#24589975)
Parent post is right though, we don't have good evidence for mask wearing.

Here's a recent, high quality, paper in a high impact paper.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

> Although direct evidence is limited, the optimum use of face masks, in particular N95 or similar respirators in health-care settings and 12–16-layer cotton or surgical masks in the community, could depend on contextual factors; action is needed at all levels to address the paucity of better evidence. Eye protection might provide additional benefits. Globally collaborative and well conducted studies, including randomised trials, of different personal protective strategies are needed regardless of the challenges, but this systematic appraisal of currently best available evidence could be considered to inform interim guidance.

There's a bit to unpack here.

1) I don't know anyone wearing a 12 to 16 layer cotton mask. At best they're wearing 4 to 6 layers of cotton. Most people have maybe two layer masks.

2) "paucity of better evidence" isn't how I'd describe something that has great evidence.

Look at how that paper describes the evidence for distancing vs masking:

> Our search identified 172 observational studies across 16 countries and six continents, with no randomised controlled trials and 44 relevant comparative studies in health-care and non-health-care settings (n=25 697 patients). Transmission of viruses was lower with physical distancing of 1 m or more, compared with a distance of less than 1 m (n=10 736, pooled adjusted odds ratio [aOR] 0·18, 95% CI 0·09 to 0·38; risk difference [RD] −10·2%, 95% CI −11·5 to −7·5; moderate certainty); protection was increased as distance was lengthened (change in relative risk [RR] 2·02 per m; pinteraction=0·041; moderate certainty). Face mask use could result in a large reduction in risk of infection (n=2647; aOR 0·15, 95% CI 0·07 to 0·34, RD −14·3%, −15·9 to −10·7; low certainty), with stronger associations with N95 or similar respirators compared with disposable surgical masks or similar (eg, reusable 12–16-layer cotton masks; pinteraction=0·090; posterior probability >95%, low certainty).

All of the mask evidence says "low certainty". That's from GRADE, and it means "low certainty (our confidence in the effect estimate is limited; the true effect could be substantially different from the estimate of the effect);"

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by garyrob on Friday September 25, 2020 @09:53AM (#24589681)
Somebody posted in response to your original post that it took them 30 seconds to find this: https://www.nature.com/articles/s41591-020-0843-2

Does it influence your position on whether or not masks are useful?

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by DanBC on Friday September 25, 2020 @10:44AM (#24590316)
That paper says "when you put a mask on, and we immediately ask you to exhale onto a plate, we don't detect virus on that plate".

Parent poster isn't asking whether masks trap particles or not (clearly, they do), they're asking a much more interesting and useful question which is if we make everyone wear a mask does that prevent the spread of disease or not?

So far, we really don't have much evidence. In this thread, where lots of people are posting links, there's only one decent link posted by gameswithgo here:

https://news.ycombinator.com/item?id=24589569

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tboyd47 on Friday September 25, 2020 @11:10AM (#24590608)
I replied in place.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by Loughla on Friday September 25, 2020 @09:54AM (#24589685)
So now that several other posters have given you several different links, are you modifying your stance at all? If not, why not?
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by wyldfire on Friday September 25, 2020 @09:56AM (#24589714)
Please do not feed the trolls.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by DanBC on Friday September 25, 2020 @10:37AM (#24590242)
So far only one person has posted a link that answers OPs question, so it was a reasonable question to ask.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by CulturalOstrich on Friday September 25, 2020 @09:38AM (#24589559)
So until you see one which side of the fence do you land on? Wearing a mask or not wearing one?
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by SketchySeaBeast on Friday September 25, 2020 @09:53AM (#24589675)
And importantly - why? Where does the risk/reward chart get so skewed that wearing a piece of cloth that can only barely be considered uncomfortable become an option that's unthinkable? It seems entirely plausible that it could help, what is the harm in trying it? It takes a lot of mental twisting to end up in a place where the potential risk of wearing a mask is larger than the potential reward.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by jlokier on Friday September 25, 2020 @10:40AM (#24590277)
I agree with you. It's just some cloth, why is it such a big deal to wear it. I wear one all the time, don't even notice after a while. It's slightly inconvenient, but only trivially so. If we all do it it almost certainly saves a significant number of lives and misery, "evidence" or not. The explanations behind it make perfect sense. And it makes people feel safer as well. All good things, for a trivial inconvenience.

The debate reminds me of the debate about smoking.

For a long time, smoking "probably" caused cancer. Meaning, almost certainly. There was plenty of evidence.

But for a long time, cigarette companies said it wasn't "proven" that it caused cancer. Meaning, let's carry on selling, advertising, consuming it in large quantities.

It would take a few more decades to reach the standard of "proof".

So smoking continued, people died.

Rather than following rational life-optimising behaviour based on the growing body of data.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tboyd47 on Friday September 25, 2020 @10:53AM (#24590442)
It may not bother you, but it makes some people very uncomfortable. Do you not think it's somewhat entitled and privileged to assume that your own standard of what's convenient and what's not convenient should be applied to everyone?

As you illustrated in your example, the medical establishment is often disastrously wrong, so why shouldn't we take their recommendations with a grain of salt?

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by jlokier on Friday September 25, 2020 @11:16AM (#24590679)
It's uncomfortable for some people to not smack me in the mouth when they walk past me in the street.

They have to take a little care where they swing their arms.

In fact some people don't take that much care, and we usually say it is the people who physically dominate a space by being inconsiderate of others who are acting entitled and privileged.

So no, I don't think it's entitled or privileged to ask people to reduce significant[+] aggregate harm to others, at minor inconvenience to themselves.

However, I think it's entitled and privileged for people to decide that they don't have to wear a mask based on their "personal risk assessment for themselves", on the theory that other people can just quit their jobs or whatever and stay locked up at home to feel safe from the unmasked crowds outside. That's the "if people want to feel safe they can stay at home if they want" theory. That's not a reasonable imposition, and does not constitute the reasonable balance of needs that we'd call a free society.

For those for whom it's particularly uncomfortable, I don't know the policy elsewhere, but in the UK, it's permitted to not wear a mask if you have a reason for not wearing one. Reasons are quite reasonable: For example if you're with someone who lip reads, or they give you anxiety or whatever.

The goal is to ensure that almost all people wear one, not that every last person must wear one if they have a reasonable reason not to.

The reason for enforced policy is because too many people won't wear one at all without a stronger incentive. Just asking people to not harm others isn't enough, it seems. (And people really can't get their intuitions around exponential growth and clustering, so they mis-estimate aggregate risks to others by a lot, even when they have numbers to go on.)

[+] (It affects the R number. The difference between R > 1 and R < 1 is pandemic versus disease dying out. It's also the difference between a long pandemic with onerous economic and social consequences, and something that is manageable. The overall effect is profoundly significant in aggregate.)

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by DanBC on Friday September 25, 2020 @10:37AM (#24590234)
Masks are often recommended as "source control" -- if an infected but asymptomatic person wears one they reduce the risk of spreading the illness to others. The bit that goes unsaid is "a good quality mask, such as a 12 to 16 layer DIY cotton mask, or a properly fitted N95, worn properly, with excellent hand hygiene when putting it on or taking it off".

The problem with that framing is that most people quickly drop the "asymptomatic" bit, and so now we have people with symptoms going shopping wearing a mask. That mask isn't going to do much to protect other people, especially when you consider it's likely to be 2 layers of cotton, poorly fitted, with poor hand hygiene.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by SketchySeaBeast on Friday September 25, 2020 @10:40AM (#24590276)
But that's not an argument against masks at all. It's an issue with education, but I have no faith that taking away the masks would have those people who are making bad decisions somehow make better decisions.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by wyldfire on Friday September 25, 2020 @09:34AM (#24589510)
Whether the mandate is effective isn't as critical as knowing whether the mask itself is effective. Knowing that they're effective opens up lots of policy options, one of which is a mandate.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314683/

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tboyd47 on Friday September 25, 2020 @10:15AM (#24589942)
The link itself appears to contradict your statement.

> The difference in conclusions of mask effectiveness studies is mainly due to different study contents, study designs, evaluation methods and endpoints. Understandably, good evidence on this topic is difficult to assess.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by wyldfire on Friday September 25, 2020 @11:33AM (#24590875)
You have cherry-picked this statement presumably because it's a part of the article that concedes genuine inconsistencies among prior studies. The study I cited seeks to explain the differing conclusions of prior studies.

But the study's support for masks is crystal clear and you can't read the entire study (or even the abstract) and come away without that conclusion.

The more I engage with you the more I fear that you are not debating the subject in good faith.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tboyd47 on Tuesday September 29, 2020 @01:23PM (#24630499)
It's just a sloppily-written study. There are spelling and grammar errors all over the place, and it's full of unsubstantiated claims that are hard to take seriously at face value. It's hard for me to even call this a study.

> However, in many western advanced economies, those wearing masks are often met with suspicion in public, even causing panic in certain situation.

Really? Citation needed.

> Although the 1918 Pandemic (H1N1 virus) caused an estimated 40–50 million deaths worldwide, many still may view personal protective equipment (PPE) and physical barrier including wearing the mask as contrary to freedom and individualism.

Non-sequitur alert! Number one, PPEs themselves are value-neutral; it's the mandate that contrary to liberty as enshrined in the Constitution (you know, the highest law in the land). Number two, mask mandates can be both effective in slowing viral spread AND "contrary to freedom and individualism;" the two concepts are orthogonal. Most people understand this, but differ in prioritizing one over the other. The author seems to suggest that the two cannot be believed at once!

Are we all supposed to just take it for granted that masks would have helped in a situation that took place over 100 years ago before so many other medical advances? I don't think that's a fair assumption at all. If so, we could just invoke the Spanish Flu as evidence for any medical intervention we desire.

Omissions like these make it hard for me to take this study as authoritative about anything, especially when they themselves admit that the evidence on universal masking is contradictory.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by chosenbreed37 on Friday September 25, 2020 @09:59AM (#24589749)
It's a fair question. One could argue that it doesn't really matter. We often take comfort from a large body of evidence supporting a course of action. Let's assume we don't have that in this case. Could we not invert the question? I.e. is there evidence that wearing (or the mandate) masks increases the spread of the virus? Or could we relax our need for evidence and use the precautionary principle? That is to say one may have doubts about what is being said about the virus but to be on the safe side wear the mask anyway.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by DanBC on Friday September 25, 2020 @10:32AM (#24590179)
That's not how the precautionary principle works, no matter how much Greenhalgh repeats it.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by gameswithgo on Friday September 25, 2020 @09:39AM (#24589569)
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tboyd47 on Friday September 25, 2020 @10:37AM (#24590239)
Thank you. Interesting stuff. This is the only study I've seen that actually presents evidence for masks slowing the spread. The comment section is a worthwhile read, too. I would like to see another study like this that's more recent, given that some locales started their mask mandate after May 15. I would also like to see if there's an effect on deaths and hospitalizations (the idea being, if mask mandates only slow the growth of asymptomatic cases, they are quite useless from a health perspective).
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by jlokier on Friday September 25, 2020 @10:45AM (#24590324)
> if mask mandates only slow the growth of asymptomatic cases, they are quite useless from a health perspective

If mask mandates slow the growth of asymptomatic cases, the R number must be lower.

As we all should know by now, reducing R is a good target, as the difference between R > 1 and R < 1 is profound, and R is thought to be close enough to 1 that measures taking place can make that difference.

This is very useful from a health perspective.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by gameswithgo on Friday September 25, 2020 @12:15PM (#24591350)
i would like for everyone to just put a mask on and quit trying to appear clever.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by daveevad on Friday September 25, 2020 @11:12AM (#24590639)
> Because mask wearing by infected people can reduce transmission risk, and because of the high proportion of asymptomatic infected individuals and transmissions, there appears to be a strong case for the effectiveness of widespread use of face masks in reducing the spread of COVID-19. However, there is no direct evidence thus far on the magnitude of such effects, especially at a population level.

Thank you for the link.

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by adrianN on Friday September 25, 2020 @09:40AM (#24589576)
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by DanBC on Friday September 25, 2020 @10:24AM (#24590077)
Did you read that study? I'm surprised that you think it's relevant to parent post's question.
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tzs on Friday September 25, 2020 @04:45PM (#24593917)
How is it not relevant to that question?
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by doesnotexist on Friday September 25, 2020 @11:19AM (#24590709)
https://jamanetwork.com/journals/jamainternalmedicine/fullar...

Summary: "investigators found that the prevalence of COVID-19 antibodies among hospital employees was lower than what had been reported for the surrounding general community that is consistent with personal protective equipment being effective at preventing exposure of hospital workers. In addition, researchers found via laboratory testing that N95 masks with intact elastic straps or if sterilized maintained their effectiveness even if they had passed their expiration point, offering alternatives to the scarcity of N95 masks."

Conclusion: "PPE, when available and properly used, confers protection and lower infection rates of COVID-19 among health care workers when compared with reported infection rates in the general public."

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by PestoDiRucola on Friday September 25, 2020 @09:36AM (#24589531)
One of the many results after a quick search: https://royalsociety.org/-/media/policy/projects/set-c/set-c...
Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by DanBC on Friday September 25, 2020 @10:31AM (#24590169)
> This paper is a pre-print and has not been subject to formal peer-review.

Not a great start

This piece, which you present as good quality evidence, says

> The lack of clear recommendations for the general public and low uptake of wearing face masks and coverings may be attributed to: (i) over-reliance on an evidence-based medicine approach and assertion that evidence was weak due to few conclusive RCT (randomised controlled trial) results in community settings, discounting high quality non-RCT evidence.

Someone asks for good quality evidence and you post a link to an opinion piece saying stop over-relying on good quality evidence?

I mean, your link even says they don't have much evidence

> Current knowledge on the effectiveness of face masks to prevent virus transmission from COVID-19, SARS, MERS and H1N1 is mostly limited to studies of surgical masks and N95 respirators. The majority of existing studies are conducted in health care settings and focus on protection of the mask wearer as opposed to wearing a mask for the protection of others. This distinction is vital since mask wearing for the general public occurs in non-clinical situations (home, public transport, shops, restaurants) and involves both protection of oneself but also others.

[...]

> We emphasise that the majority of studies have been conducted in health care settings and there are therefore caveats in the ability to transfer results directly to community settings

Re:Belief in Conspiracy Theories Is a Barrier to Controlling... by tboyd47 on Friday September 25, 2020 @10:25AM (#24590090)
> This paper is a pre-print and has not been subject to formal peer-review.