I got the impression that Paul saw many possible futures where there was certainty of a bad outcome, and some possible futures with an unknown outcome, and that the path to the unknown outcomes all involved jihad and death. So, at least in the first novel, Paul felt compelled to pursue jihad in order to provide an uncertain future, as avoiding jihad would be worse.
It's been quite some time since I read beyond the first novel though.
My interpretation is that Paul didn’t take the golden path. He felt trapped into taking it, but when twins were born, he was freed of that obligation because it opened up a future he hadn’t foreseen.
Imagine looking into your child's face and knowing the exact time and nature of his/her death. I think this is a big reason childhood diseases have the status of especially evil.