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Re:SARS-CoV-2 positivity rates associated with circulating V... by nialv7 on Saturday September 19, 2020 @05:09PM (#24530324)
Serious adversarial effect:

https://www.thedailybeast.com/chloroquine-study-ended-in-bra...

https://www.nytimes.com/2020/04/12/health/chloroquine-corona...

Revoked FDA use authorization:

https://www.fda.gov/news-events/press-announcements/coronavi...

Example of researches that doesn't see an effect of hydroxychloroquine:

https://www.nejm.org/doi/full/10.1056/NEJMoa2019014?query=RP

Edit:

However, there were researches showing hydroxychloroquine increase arrhythmia risks, which were actually based on fraudulent data and has been retracted:

https://en.wikipedia.org/wiki/Surgisphere#Lancet_and_NEJM_ar...

So the trails might be stopped prematurely. But I still believe there are not conclusive evidences currently. e.g. as shown by this meta-analysis: https://www.clinicalmicrobiologyandinfection.com/article/S11...

Re:SARS-CoV-2 positivity rates associated with circulating V... by ColanR on Saturday September 19, 2020 @05:24PM (#24530422)
> Serious adversarial effect

It's a well-understood drug, and any doctor worth their license would know how to use it safely.

> Revoked FDA use authorization

All that means is that more evidence is required before there's an official stamp of approval. "this drug may not be effective to treat COVID-19..." is what the actual request to revoke authroization said.

> Example of researches [sic] that doesn't see an effect of hydroxychloroquine

And there's other evidence contradicting that.

You said there's "no evidence" it's beneficial. That's pretty clearly false, merely based on what I already linked (maybe you should broaden your reading habits). We can debate the degree of confidence the accumulation of studies can give us, but that's outside both our leagues.

Re:SARS-CoV-2 positivity rates associated with circulating V... by tehjoker on Saturday September 19, 2020 @07:09PM (#24530897)
The "therapeutic" dose of HCQ in COVID-19 patients is usually 600mg and up. The therapeutic dose for e.g. rheumatoid arthritis is 400mg or less. These higher doses were linked to arrhythmia and very little evidence of a beneficial effect has been found.

HCQ has been used in petri dishes against many viruses and been successful there. Whenever they use it in vivo, it fails. This is not a new phenomenon. The link below is somewhat dated at this point (May 2020), but I believe it still stands.

https://www.sciencedirect.com/science/article/abs/pii/S01663...

In any case, if the FDA is saying "may not" the drug is not a slam dunk even if it has some beneficial effect. Winning the rhetorical war on HCQ isn't going to make COVID go away or be less serious in a substantial fashion.

Re:SARS-CoV-2 positivity rates associated with circulating V... by ColanR on Saturday September 19, 2020 @07:56PM (#24531067)
> Winning the rhetorical war on HCQ

You said there's "no evidence". I said you were wrong, and apparently could muster better information than you could. That's not rhetoric, that's logic and evidence.