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Re:Covid-19: Do many people have pre-existing immunity? by gnusty_gnurc on Thursday September 17, 2020 @10:59AM (#24505419)
Michael Levitt has been saying this since the Diamond Princess event.

Scratch that - he hasn't been maintaining there's pre-existing immunity, rather asking the question to anyone who'd listen...he doesn't have a background in biology, but that's one of the few conclusions he could surmise from studying the data.

Re:Covid-19: Do many people have pre-existing immunity? by apcragg on Thursday September 17, 2020 @11:52AM (#24506153)
https://www.latimes.com/science/story/2020-03-22/coronavirus... He seems to be a perfect example of the axiom that deep knowledge in one field doesn't necessarily give you expertise in others. Seems like he should leave Epidemiology to the epidemiologists.
Re:Covid-19: Do many people have pre-existing immunity? by aeternum on Thursday September 17, 2020 @12:07PM (#24506362)
Since when is that an axiom? He carefully analyzed the data and presented a falsifiable prediction along with his methodology. If he was wrong we should look at why and learn from it. (Did he fail to account for the virus mutating, could different regions have different co-morbidities or immunities?)

We should not rely on appeals to authority, those expert epidemiologists didn't do much better.

Re:Covid-19: Do many people have pre-existing immunity? by gnusty_gnurc on Thursday September 17, 2020 @12:10PM (#24506409)
He's been talking about this a lot - the (lack of) communication and debate in the science community.

People interested in truth invite criticism: "Please give me contrary evidence! Show me I'm wrong!"

Re:Covid-19: Do many people have pre-existing immunity? by ineedasername on Thursday September 17, 2020 @01:00PM (#24507079)
"Show me I'm wrong" is not the starting point in the scientific method.
Re:Covid-19: Do many people have pre-existing immunity? by GavinB on Thursday September 17, 2020 @01:34PM (#24507483)
It kind of is. Hypothesis rejection is the primary means of advancing knowledge.

"We tried to prove this hypothesis wrong and could not" is the main thing you want a study to do. Having everyone try to prove your hypothesis wrong, and failing, is the main way that science advances.

Re:Covid-19: Do many people have pre-existing immunity? by ineedasername on Thursday September 17, 2020 @03:12PM (#24508696)
No, really, it is not. In your own example you're already jumping to testing a hypothesis. "Scientific method" isn't just a vague phrase, there literally is a specific method of steps to go through.

The first step is Observation. Sometimes split out into Observation, then Research.

Then comes the formulation of a hypothesis.

After that is constructing a way to test the hypothesis. Not to prove it wrong, not to prove it right, but to test it.

There's more after that, it's an iterative process and a single test of a hypothesis isn't always definitive, often it is not. But "Prove me wrong" is not the starting point.

Re:Covid-19: Do many people have pre-existing immunity? by gamblor956 on Thursday September 17, 2020 @02:28PM (#24508241)
No, science proceeds on the basis of trying to prove a hypothesis is correct. As in, I hypothesize A should B, evidence XYZ supports this.

You accomplish very little trying to prove a hypothesis wrong, because most are.

Re:Covid-19: Do many people have pre-existing immunity? by disgruntledphd2 on Thursday September 17, 2020 @03:27PM (#24508876)
While you are correct conceptually, most scientific research using statistics does in fact attempt to provide evidence against no-effect (the null hypothesis).

The p-value of a scientific study is the probability that the given data would have been observed, given that there is no effect. Hence why small p-values can be associated with the success of the alternative hypothesis (i.e. what a scientist actually thinks will happen).

Re:Covid-19: Do many people have pre-existing immunity? by RobertoG on Thursday September 17, 2020 @03:32PM (#24508930)
We should remember Popper (1).

You can't prove an hypothesis is correct. All models are temporal until they are disprove.

(1) - https://en.wikipedia.org/wiki/Falsifiability

Re:Covid-19: Do many people have pre-existing immunity? by roelschroeven on Friday September 18, 2020 @11:30AM (#24518037)
I know some people who tap a can of Coke before they open it, because "that prevents it from spilling". Each time they do that, they are more convinced that their hypothesis is correct.

But is it correct? To find out, we need to try to invalidate it. Try opening the can without tapping it first. If the Coke doesn't spill, the hypothesis is clearly wrong. It the Coke does spill now, it's quite strong evidence in favor of the hypothesis.

Re:Covid-19: Do many people have pre-existing immunity? by mav3rick on Thursday September 17, 2020 @03:02PM (#24508600)
Lol no ! You prove a hypothesis to be correct.
Re:Covid-19: Do many people have pre-existing immunity? by gnusty_gnurc on Thursday September 17, 2020 @01:31PM (#24507451)
It's something that's felt by scientists who've developed a hypothesis they want verified. Keen interest in explanations of data, etc.
Re:Covid-19: Do many people have pre-existing immunity? by 13415 on Thursday September 17, 2020 @01:25PM (#24507373)
> those expert epidemiologists didn't do much better.

How did you arrive at this assessment? I've been following this since the end of January, and every expert I've heard gave sound and very good advise based on the available evidence at that time. Some of them might have made some disputable trade-offs, for example the Swedish lead epidemiologist, but overall there was a lot of agreement and the recommendations were excellent.

Okay, maybe there are a few outlier countries like the US and Brazil where there might have been political muddling of the expert messages. Be that as it may, in general the advice from experts was not only good, most countries also succeeded in controlling the spread of the virus based on it. (And not every country needs to implement the same measures to be successful in that, it's more about a mix that works in that country.)

Re:Covid-19: Do many people have pre-existing immunity? by beagle3 on Friday September 18, 2020 @05:21PM (#24521989)
Those experts at the WHO predicted, in March, that if Sweden does not enforce a lockdown as recommended by the WHO, it will have 96,000 deaths on 1-July.

The non-expert Michael Levitt, predicted at the same time, by fitting 3 parameters of a Gompertz distribution (And no other knowledge), that Sweden will have 5000 deaths on 1-July if things continue as they were when he made the prediction (that is, no WHO recommended lockdown).

I'll leave it to you to lookup the Swedish death count on 1-July to see if the expert epidemiologists from the WHO had a better idea than non-expert Levitt. (But I'll give you a hint: It is mid september, and Sweden has ~6000 deaths).

Re:Covid-19: Do many people have pre-existing immunity? by 13415 on Sunday September 20, 2020 @10:12AM (#24534151)
Nonsense, and also irrelevant. You're picking out one predictive model that got it wrong. I'd like to see this model, by the way. I've seen numerous models that got it right, and in any case I was talking about the advice experts gave. Nobody doubts that Sweden's death toll would be much lower if they had done a lockdown like almost every other country. In fact, the Swedish lead epidemiologist admitted that mistakes were made and that they failed to protect the elderly.

The WHO advice was much better than what Swedish advisors came up with.

Besides that, I was not talking about WHO experts but about experts in general. Every country has them, and they supply the data to WHO.

Last but not least, you cannot evaluate a model on the basis of a singular prediction.

Re:Covid-19: Do many people have pre-existing immunity? by 50ckpuppet on Thursday September 17, 2020 @12:05PM (#24506334)
bingo. Maybe why actors should stick to acting ?
Re:Covid-19: Do many people have pre-existing immunity? by tboyd47 on Thursday September 17, 2020 @11:51AM (#24506137)
It is encouraging that real scientists (not just "pro-science" laymen) seem to be listening to these ideas and producing studies on them while the media ignores and ridicules them.