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Re:Covid-19: Do many people have pre-existing immunity? by ineedasername on Thursday September 17, 2020 @01:00PM (#24507079)
"Show me I'm wrong" is not the starting point in the scientific method.
Re:Covid-19: Do many people have pre-existing immunity? by GavinB on Thursday September 17, 2020 @01:34PM (#24507483)
It kind of is. Hypothesis rejection is the primary means of advancing knowledge.

"We tried to prove this hypothesis wrong and could not" is the main thing you want a study to do. Having everyone try to prove your hypothesis wrong, and failing, is the main way that science advances.

Re:Covid-19: Do many people have pre-existing immunity? by ineedasername on Thursday September 17, 2020 @03:12PM (#24508696)
No, really, it is not. In your own example you're already jumping to testing a hypothesis. "Scientific method" isn't just a vague phrase, there literally is a specific method of steps to go through.

The first step is Observation. Sometimes split out into Observation, then Research.

Then comes the formulation of a hypothesis.

After that is constructing a way to test the hypothesis. Not to prove it wrong, not to prove it right, but to test it.

There's more after that, it's an iterative process and a single test of a hypothesis isn't always definitive, often it is not. But "Prove me wrong" is not the starting point.

Re:Covid-19: Do many people have pre-existing immunity? by gamblor956 on Thursday September 17, 2020 @02:28PM (#24508241)
No, science proceeds on the basis of trying to prove a hypothesis is correct. As in, I hypothesize A should B, evidence XYZ supports this.

You accomplish very little trying to prove a hypothesis wrong, because most are.

Re:Covid-19: Do many people have pre-existing immunity? by disgruntledphd2 on Thursday September 17, 2020 @03:27PM (#24508876)
While you are correct conceptually, most scientific research using statistics does in fact attempt to provide evidence against no-effect (the null hypothesis).

The p-value of a scientific study is the probability that the given data would have been observed, given that there is no effect. Hence why small p-values can be associated with the success of the alternative hypothesis (i.e. what a scientist actually thinks will happen).

Re:Covid-19: Do many people have pre-existing immunity? by RobertoG on Thursday September 17, 2020 @03:32PM (#24508930)
We should remember Popper (1).

You can't prove an hypothesis is correct. All models are temporal until they are disprove.

(1) - https://en.wikipedia.org/wiki/Falsifiability

Re:Covid-19: Do many people have pre-existing immunity? by roelschroeven on Friday September 18, 2020 @11:30AM (#24518037)
I know some people who tap a can of Coke before they open it, because "that prevents it from spilling". Each time they do that, they are more convinced that their hypothesis is correct.

But is it correct? To find out, we need to try to invalidate it. Try opening the can without tapping it first. If the Coke doesn't spill, the hypothesis is clearly wrong. It the Coke does spill now, it's quite strong evidence in favor of the hypothesis.

Re:Covid-19: Do many people have pre-existing immunity? by mav3rick on Thursday September 17, 2020 @03:02PM (#24508600)
Lol no ! You prove a hypothesis to be correct.
Re:Covid-19: Do many people have pre-existing immunity? by gnusty_gnurc on Thursday September 17, 2020 @01:31PM (#24507451)
It's something that's felt by scientists who've developed a hypothesis they want verified. Keen interest in explanations of data, etc.