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A comment on AstraZeneca Covid-19 vaccine study put on hold due to suspected adverse reaction. Parent comment

Re:AstraZeneca Covid-19 vaccine study put on hold due to sus... by thehappypm on Tuesday September 08, 2020 @08:45PM (#24415405)
It’s disingenuous to call it “the Moderna mRNA vaccine” when it was more accurately “one early Moderna mRNA vaccine candidate, which was ruled out for being far too high of a dose”.
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Re:AstraZeneca Covid-19 vaccine study put on hold due to sus... by zerobits on Tuesday September 08, 2020 @10:48PM (#24416398)
Thanks for the valid correction.

I didn’t mean to be disingenuous. I forgot they rejected that dosage.

Overall, the picture does look potentially concerning for the side effects of that vaccine and efficacy is still unclear.

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Re:AstraZeneca Covid-19 vaccine study put on hold due to sus... by thehappypm on Tuesday September 08, 2020 @11:44PM (#24416836)
What makes it concerning? Tylenol is concerning if you take 2.5x the safe dose. Of course the efficacy is unclear — it’s still in trials!
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Re:AstraZeneca Covid-19 vaccine study put on hold due to sus... by zerobits on Wednesday September 09, 2020 @02:10AM (#24417770)
There was a pretty high severe systemic adverse rate in the high dose group (20%). Severe local response rate was 5% in the middle dose. [1]

I have no idea how this compares to other vaccines, and you can pessimistically extrapolate a bit from this tiny, healthy sample from the high dose (n=15 in middle dose group).

I'd imagine some % of people when this scales to millions will have a bad response, and the high dose group might provide some model of the worst cases.

[1] https://www.nejm.org/doi/full/10.1056/nejmoa2022483

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Re:AstraZeneca Covid-19 vaccine study put on hold due to sus... by DrAwdeOccarim on Wednesday September 09, 2020 @05:44AM (#24419194)
I think the comparison most are making is to Shingrix. Have a look at Table 2[1].

[1] https://www.nejm.org/doi/pdf/10.1056/NEJMoa1603800

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