>A drug on the market for 60 years (and over the counter in many countries) is “extremely dangerous

Tylenol has been on the market for a 60 years, often over the counter, but off label recommendations involving a high dose could be deadly. Drugs should always be considered "extremely dangerous."

Anything in high dose can be dangerous. So that's not helpful.

Anything. For instance, water.

Yep, taking ~8 extra strength Tylenol twice a day is comparable to drinking however many gallons of water a day you would need to cause problems.

> A drug on the market for 60 years (and over the counter in many countries) is “extremely dangerous”?

Yes it can, if used in a different context. You can't generalize stuff in medicine. There are hundreds of factors in play: co-morbidities, genetics, interacting drugs, timelines, dosages, dose delivery forms, routes of entry, previous surgical procedures, demographics...

>more likely because it’s out of patent there’s a lot of money interested in exploring other things as a treatment

HCQ was not even remotely controversial until Trump tweeted about it.

Our institutions have lost their collective minds with their spiteful, childish hatred for a politician. Academia and news media have completely lost sight of objectivity.

People started hoarding HCQ in early February when the first Chinese studies were coming out. Didier Raoult's (crazy looking French doctor) reports in mid-March sparked the first controversies. I remember worrying at that point there'd be some big-pharma-backed media operation to discredit a cheap, patent-expired drug since there are trillions of dollars at stake. Trump tweet was in late March.