Re:Coronavirus could attack T lymphocytes like HIV [pdf]
by jonplackett on Tuesday April 14, 2020 @06:33AM
(#22864409)
If it does not replicate, does that mean it doesn't harm the cell it enters?
Re:Coronavirus could attack T lymphocytes like HIV [pdf]
by djmips on Wednesday April 15, 2020 @11:23PM
(#22885720)
I also wondered that. Even if it doesn't replicate inside a T lymphocyte could it damage it thereby weakening the immune response as a side effect?
Re:Coronavirus could attack T lymphocytes like HIV [pdf]
by jonplackett on Thursday April 16, 2020 @04:29AM
(#22887328)
To a complete layperson (myself) it seems that anything entering a cell it's not supposed to isn't going to help that cell out much. I would appreciate some expert commentary though if anyone has some!
Re:Coronavirus could attack T lymphocytes like HIV [pdf]
by libertine on Tuesday April 14, 2020 @07:18AM
(#22864659)
This is a question out of ignorance, but couldn't this be a precursor of a potential strain (one that, through a mutation, can start replicating on MT-2 cells?). Like this could be a dead end for the virus, until it's not?
Or this potential is irrelevant, because tracking all potential mutations/strains simply makes no sense?
So it infects the cells but it's a dead end for the virus.
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I can't believe the journal published the article with that clickbait title, without mentioning that it's non-productive infection. I was about to dig up the transcriptomics paper (cited by this paper) and the pre-print about the virus decimating the spleen/lymphoid organs which show that T cells aren't infected (I guess they are technically infected, but not in the way most people think).
(Quick CP from Reddit)