Look with suspicion on any in vitro data. There are so many differences between in vitro and a living organism. Nevermind the fact that in vitro tests usually use concentrations that would never be achieved in the body, a fact usually lost on the public. I’d definitely lean towards the “aspirin is bad with Coronavirus” camp on this one.

Source: Myself, a former tester of in vitro effects.

> Nevermind the fact that in vitro tests usually use concentrations that would never be achieved in the body, a fact usually lost on the public.

But the reason large doses are used in vitro is because it's easier to show that a chemical actually inhibits viral replication if you can slow down replication by 99.9%. But in real life, you might only need to slow down replication by 10% or whatever to meaningfully improve clinical outcomes.

That's true in theory and we should see aspirin doing something in vivo for coronavirus if it did, but we don't. Something else more important seems to be affecting it the other way.

In skimming the article it seems they used 20 mM doses and ranges which is an absolutely enormous amount of anything. We normally considered low uM the range where something is even beginning to be interesting.

Yeah about the in vitro thing.. I'm sure gasoline also kills the corona virus. Unfortunately the patient also goes.

Aspirin is a blood thinner it might cause your lungs to bleed once they sustain enough damage to their epithelial layer which might make your pneumonia worse.

>This study was done in vitro. If I recall the counterindication of aspirin in C19 patients was accelerating pneumonia or something. So it's possible aspirin does both.

Relavent: https://xkcd.com/1217/