I still don't get it. The goal is to have your $HOME-directory on an usb-stick and use it on different computers?

That would require having the same software versions installed on every system. But even then it wouldn't work because the user-settings stored in $HOME might depend on the hardware, e.g. monitor setup etc.

I think this is not for private users but for companies where the same or similar software and hardware configuration is used across systems.

Usually in configurations like that, the org likes having the ability to scan user home directories at will, for a variety of reasons. In my experience in those kind of networks, home directories are often on a centralized NFS/CIFS server.

Monitor setup is already a problem, I regularly switch between laptop screen, 1 monitor, 2 monitors or a TV.