Ergodox EZ may puzzle people with its layout, but the split island part alone has made computing comfortable for me, especially when combined with a sit/stand desk. There's a lot less physical strain to wrestle with, which a bigger difference as time goes on.
I've tried split keyboards. They feel unnatural. I feel like I type better/faster when my hands are closer together.
The single greatest thing I've ever done to completely cure RSI pain while typing is eliminating "wrist yaw" - i.e., maintaining a mostly straight line from my elbow to my knuckles. The bonus is that I can type comfortably on any keyboard.
ymmv, obvs.
I defined custom layers so that I can toggle a layer on depending on whether I'm using the keyboard with Chrome OS or Ubuntu Linux. This allows me to use the same shortcuts between the two OSes, while they are otherwise not customizable on Chrome OS. Also, it allows me to use media keys for Chrome OS on a split/ergo keyboard.
Plus as a Vim user, I'm able to use HJKL arrow keys in any app on either OS.
My layout is here:
https://configure.ergodox-ez.com/ergodox-ez/layouts/3vzB7/GZ...
This is how I feel about the Qwerty keyboard layout.
Then, I put the keyboards there, adjust the desk up to that height, and put books under the monitor until the center is exactly level with my eyes. Trackball to the right.
This is dramatically more comfortable than anything else I could be doing. It's hard to convey how uncomfortable a straight keyboard is to someone who hasn't tried the alternative.