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A comment on Psilocybin for major depression granted Breakthrough Therapy by FDA. Parent comment

Re:Psilocybin for major depression granted Breakthrough Ther... by sibeliuss on Tuesday November 26, 2019 @02:11PM (#21641550)
It is imperative that you do not combine psychedelics with antidepressants! This can lead to dangerous side effects / behaviors! If you take a combination of drugs this is even more important to heed.

The proper path is to wean yourself off of the antidepressants for the experience, and then only undertake the experience with an experienced sitter or guide.

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Re:Psilocybin for major depression granted Breakthrough Ther... by xorfish on Tuesday November 26, 2019 @02:46PM (#21641919)
https://wiki.tripsit.me/images/3/3a/Combo_2.png

Psilocybins effect is enhanced by MAOI and decreaces by SSRIs. LSD effects are decreased by both. With other other psychedelics you have to be a bit carefull.

You probably think of MDMA and MAOIs, this would be a dangerous combination.

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Re:Psilocybin for major depression granted Breakthrough Ther... by mirimir on Tuesday November 26, 2019 @03:14PM (#21642198)
Yes, MAOI dramatically increase and prolong effects of DMT.

And indeed, that's what ayahuasca (aka yage) is.

Plus various mushrooms and other psychoactive stuff, depending on the preferences of the curandeiro/a (shaman) and the intended outcome.

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Re:Psilocybin for major depression granted Breakthrough Ther... by Frondo on Tuesday November 26, 2019 @03:19PM (#21642252)
It absolutely depends on the anti-depressant.

SSRIs, do not mix.

NDRIs, lots of people report they're fine.

Hopefully we'll get better data on what other chemicals are okay to mix as these things slowly become permitted to be the subjects of study.

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