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A comment on Psilocybin for major depression granted Breakthrough Therapy by FDA. Parent comment

Re:Psilocybin for major depression granted Breakthrough Ther... by xorfish on Tuesday November 26, 2019 @02:46PM (#21641919)
https://wiki.tripsit.me/images/3/3a/Combo_2.png

Psilocybins effect is enhanced by MAOI and decreaces by SSRIs. LSD effects are decreased by both. With other other psychedelics you have to be a bit carefull.

You probably think of MDMA and MAOIs, this would be a dangerous combination.

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Re:Psilocybin for major depression granted Breakthrough Ther... by mirimir on Tuesday November 26, 2019 @03:14PM (#21642198)
Yes, MAOI dramatically increase and prolong effects of DMT.

And indeed, that's what ayahuasca (aka yage) is.

Plus various mushrooms and other psychoactive stuff, depending on the preferences of the curandeiro/a (shaman) and the intended outcome.

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