I took six months off after a large liquidity event and then went back into the job market. I don't think I lost any negotiating power - the trick was to make sure I times the interviews so that I'd have several offers at the same time and then could use the fact that company X was offering a certain amount to ensure I got the job at the company I liked the most.

I do just want to say one thing: most tech investors now think we are in a bubble. A downturn is likely at some point. Now would be a very good time to ensure you have six months of expenses in a savings account so you don't have to take the first job you get offered - I had to do that in 2008 after the financial crisis hit and my startup died and it wasn't a fun time.