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Re:Acute Effects of Electronic Cigarette Aerosol Inhalation ... by 01100011 on Wednesday August 21, 2019 @06:46PM (#20762743)
Nicotine only makes me sick. I've tried gums, vapes, and nicotine salt pouches. I smoke a tobacco pipe when I want to relax.

There are MAOIs in tobacco smoke. I'm not sure that's what makes me feel calm though.

Re:Acute Effects of Electronic Cigarette Aerosol Inhalation ... by Jarwain on Wednesday August 21, 2019 @07:26PM (#20763021)
It could be the interaction between the MAOIs and the nicotine. Or more accurately, the MAOIs altering how your body handles nicotine.
Re:Acute Effects of Electronic Cigarette Aerosol Inhalation ... by caymanjim on Wednesday August 21, 2019 @07:59PM (#20763264)
There are sibling comments discussing MAOIs, and I've heard about them before in relation to smoking. It makes me wonder if MAOIs alone would be better for smoking cessation. I don't think I'm all that addicted to the nicotine itself. There are plenty of other supposedly-addictive stimulants that I can take or leave at will and with no feelings of withdrawal, and nicotine does nothing to alleviate cigarette withdrawal for me, so I'm not sure it's even a necessary component. There are some NIH studies about MAOIs and smoking, but I'm not going to link them because I find them incomprehensibly dense.
Re:Acute Effects of Electronic Cigarette Aerosol Inhalation ... by tonyarkles on Wednesday August 21, 2019 @08:30PM (#20763461)
I don’t remember what family of antidepressant Bupropion (Wellbutrin/Zyban) is, but it helped me immensely the first time I quit. I literally just woke up one day (a few days before my target quit date) and had no craving at all.

It also made me a little bit manic, and weaning off it sucked, but it worked well in general.