Yes, it’s true. A special PySC interface was created for AI. Also, it’s not only that AI doesn’t need to parse information available on much limited screen real estate but also that AI doesn’t have to use controller that have physical constraints. So AI has access to this super human controller and it can decide to click on one screen extreme and then another within 200ms.

Any game that is specifically going out of its way to support these ai’s will naturally do it through an api, though I’m only aware of dota2 and sc2 (sc:bw also does, through a community-modified client that serves the api, iirc). For adhoc games, eg atari, pixel-parsing is the natural result, but no one would intentionally set it up like that