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Re:Compass Pathways has set itself up to be the first legal ... by jessaustin on Friday January 04, 2019 @11:12AM (#18825036)
This is a natural product. One can grow it in the basement of one's home. One can gather it where it grows wild. (Ask me how I know!) No user of this product has ever harmed anyone else as a result of using it. Any restrictions at all on this product could only ever be tyrannical. Let's not abide tyranny, ok?
Re:Compass Pathways has set itself up to be the first legal ... by neom on Friday January 04, 2019 @11:27AM (#18825204)
I'm a huge advocate for and fan of psilocybin but I'd suggest taking some time to read through the Erowid psilocybin trip reports, there are many reports of people inadvertently causing a great deal of grief for others while tripping.
Re:Compass Pathways has set itself up to be the first legal ... by johnwyles on Friday January 04, 2019 @01:38PM (#18826489)
I too am an advocate but willing to bet you some scratch that the incidence of grief, harm, or violence from someone tripping on mushrooms versus a tee-totalling sober population is lower. You went directly to the most formidable source for reporting trips and they even break it down by bad experiences vs good vs etc. so of course you're going to find some stories that exist.
Re:Compass Pathways has set itself up to be the first legal ... by neom on Friday January 04, 2019 @02:01PM (#18826681)
I'd be willing to bet you're right, but I'd also be willing to bet if we go out there playing it loose and fast like Timothy Leary, not much will change, and that would be a damn shame. Just because the risks are low, doesn't mean people shouldn't be educated to the risks, as I'm sure you'd agree, good education on entheogens helps create the foundation for the most important aspects of set and setting. I'm not trying to be a pedantic asshat, I genuinely believe statements like "No user of this product has ever harmed anyone else as a result of using it" are not helpful. Peace. <3
Re:Compass Pathways has set itself up to be the first legal ... by lenzm on Friday January 04, 2019 @11:23AM (#18825161)
I think I'm on the same side as you, but you don't help your case by making wild claims like:

> No user of this product has ever harmed anyone else as a result of using it

Re:Compass Pathways has set itself up to be the first legal ... by jessaustin on Friday January 04, 2019 @09:59PM (#18829608)
I don't care to make a "case". I'm interested in any examples of contradictions to this claim. So far my interest has not been satisfied in this thread...
Re:Compass Pathways has set itself up to be the first legal ... by catcow on Monday January 07, 2019 @03:45AM (#18843740)
The absence of evidence does not indicate evidence of absence.

Physical harm is rare in psychedelic experiences. Psychological harm is very, very real and has destroyed peoples lives when they get too carried away using psychedelics. I agree that these compounds should be legal, but to say they are 100% safe is ridiculous.

Re:Compass Pathways has set itself up to be the first legal ... by waynecochran on Friday January 04, 2019 @11:29AM (#18825225)
I really don't know much about it beyond the anecdotes I've heard from friends and others, but aren't there cases of psychotic behavior (going berserk) and also suicide? BTW, I wouldn't use the term "natural" as an indicator of how benign it is -- the following are also natural: arsenic, anthrax, mercury, water hemlock, and castor beans.
Re:Compass Pathways has set itself up to be the first legal ... by jcoffland on Friday January 04, 2019 @02:38PM (#18827016)
Not to mention Amanita Ocreata or A. Phalloides.
Re:Compass Pathways has set itself up to be the first legal ... by waynecochran on Friday January 04, 2019 @03:40PM (#18827402)
That is why I never eat mushrooms that rely on my ability to identify them.
Re:Compass Pathways has set itself up to be the first legal ... by Matticus_Rex on Friday January 04, 2019 @05:06PM (#18828135)
I do it all the time, though I avoid a few that have poisonous lookalikes. I picked some oyster mushrooms on the way home from the grocery store today in the middle of town. Even a child can safely identify a number of great edible mushrooms.
Re:Compass Pathways has set itself up to be the first legal ... by claudiulodro on Friday January 04, 2019 @11:41AM (#18825354)
Would you say antidepressants are not dangerous to anyone even though they cause suicidal ideation in some people? One notable mushroom incident I remember is the tourist in Amsterdam that jumped off a building after using mushrooms.[1] That being said, the solution to the issue is definitely not what the company in the article is trying to do.

[1] http://www.simplyamsterdam.nl/French_tourist_in_Amsterdam_co...

Re:Compass Pathways has set itself up to be the first legal ... by jessaustin on Friday January 04, 2019 @10:03PM (#18829626)
That's not really what I was talking about. The unfortunate French girl harmed herself, but unless your link left out a relevant fact such as her having landed on someone, she didn't harm anyone else.
Re:Compass Pathways has set itself up to be the first legal ... by RyJones on Saturday January 05, 2019 @02:37AM (#18830482)
Her family might disagree that nobody else was hurt. The people tasked with cleaning her of the pavement may disagree, as well.

Not all externalities of drug use are physical.

I'm extremely pro-legalized everything. I find your callous disregard alarming.

Re:Compass Pathways has set itself up to be the first legal ... by jessaustin on Saturday January 05, 2019 @06:02AM (#18831056)
Sure, let's have a Drug War to make it easier on the sidewalk cleaners. All the murder, all the injustice, all the expense, it's totally worth it because psilocybin is the only reason anyone ever jumped off a building. "Callous disregard", indeed.
Re:Compass Pathways has set itself up to be the first legal ... by toufiqbarhamov on Saturday January 05, 2019 @10:11AM (#18831987)
I'm extremely pro-legalized everything.

How did you get from there to, Sure, let’s have a Drug War?

Re:Compass Pathways has set itself up to be the first legal ... by jessaustin on Monday January 07, 2019 @02:41PM (#18849164)
In writing that, I was just paraphrasing GP in an ironic way. Of course I don't support any Drug War. I realize that means that drugs should be legal.
Re:Compass Pathways has set itself up to be the first legal ... by RankingMember on Friday January 04, 2019 @11:48AM (#18825430)
> (Ask me how I know!)

How do you know?

Re:Compass Pathways has set itself up to be the first legal ... by jessaustin on Friday January 04, 2019 @04:36PM (#18827867)
I have gathered this product from wild-growing stands.
Re:Compass Pathways has set itself up to be the first legal ... by driverdan on Friday January 04, 2019 @11:30AM (#18825241)
> No user of this product has ever harmed anyone else as a result of using it.

That is a ridiculous statement. Anything can harm you, including water. Everything has negative side effects given a large enough dose.

Re:Compass Pathways has set itself up to be the first legal ... by black-tea on Friday January 04, 2019 @11:38AM (#18825317)
He didn't say anything about it harming the user. People should be allowed to harm themselves if they want to and most methods of self-harm are legal including using alcohol and cutting oneself.
Re:Compass Pathways has set itself up to be the first legal ... by waynecochran on Friday January 04, 2019 @11:42AM (#18825360)

    > People should be allowed to harm themselves if they want to 
As long as they pay for their own medical insurance.
Re:Compass Pathways has set itself up to be the first legal ... by daveFNbuck on Friday January 04, 2019 @12:18PM (#18825718)
This attitude is the one thing that keeps me from embracing universal government-provided health insurance. People are so quick to use it as a justification for legal restrictions on behavior.
Re:Compass Pathways has set itself up to be the first legal ... by RankingMember on Friday January 04, 2019 @02:16PM (#18826823)
I wouldn't let someone's knucklehead comment dissuade you from supporting something that would do a huge amount of good for people here in America.
Re:Compass Pathways has set itself up to be the first legal ... by daveFNbuck on Friday January 04, 2019 @08:39PM (#18829338)
My concern is that this is a popular enough sentiment that universal health care would lead to real reductions in freedom for Americans. I think it's reasonable to be concerned about anything that could contribute to current trends toward totalitarianism.
Re:Compass Pathways has set itself up to be the first legal ... by black-tea on Saturday January 05, 2019 @04:29AM (#18830741)
What freedoms does USA have that European countries with universal healthcare do not?

Bear in mind Portugal has healthcare and legalised all drugs.

Re:Compass Pathways has set itself up to be the first legal ... by daveFNbuck on Saturday January 05, 2019 @10:43AM (#18832153)
I don't know the answer to your question. In the US we already have people trying to use welfare as an excuse to mandate drug testing and control what people are allowed to eat. Maybe this sort of thing never happens elsewhere, but the US is often an outlier in how shitty we can be to people.

It's also my understanding that healthcare was a big part of what convinced people in the UK to vote for Brexit.

Re:Compass Pathways has set itself up to be the first legal ... by waynecochran on Friday January 04, 2019 @03:46PM (#18827442)
Hey, local knucklehead here. I don't want to live in a place where folks don't get the healthcare they need just because they can't afford it. OTOH, the idea that our individual choices don't affect those around us is naive. Freedom and responsibility go hand in hand.
Re:Compass Pathways has set itself up to be the first legal ... by daveFNbuck on Friday January 04, 2019 @08:36PM (#18829323)
Freedom and responsibility going hand in hand doesn't mean that hobbies with negative health consequences should be illegal.
Re:Compass Pathways has set itself up to be the first legal ... by waynecochran on Saturday January 05, 2019 @12:07AM (#18830021)
Never said illegal. If I willingly place myself in a high risk category I should pay for that myself. I may buy a wing suit someday, but I won't ask you to pay for my wheelchair.
Re:Compass Pathways has set itself up to be the first legal ... by daveFNbuck on Saturday January 05, 2019 @12:58AM (#18830201)
Should coal miners get health insurance? What about first responders?
Re:Compass Pathways has set itself up to be the first legal ... by waynecochran on Saturday January 05, 2019 @11:10AM (#18832339)
Yes. And their employers should bear much of the risk. The actuarial tables should dictate the cost.
Re:Compass Pathways has set itself up to be the first legal ... by RankingMember on Sunday January 06, 2019 @12:51AM (#18836803)
What is this fear of paying for higher risk individuals based on? That more people will start bungee-jumping and skydiving or becoming firefighters and police officers? Part of the point of a nationalized system is that the costs offset- the healthier people use less services than they're paying for, but in exchange, you get to live in a society where everyone can get care regardless of employment, hobbies, or pre-existing condition. The young pay for the old. The idea of adding a bureaucracy on top of that to try to parcel out individual risk and surcharge people sounds like it'd be an amazingly complex waste of money in itself. It also sort of reminds me of China's social credit system, but with your healthcare-cost related activities instead. Would you have to start reporting that you play a game of touch football on Thanksgiving, or that you ride your bike instead of driving a car to get to work? Maybe I walk through a neighborhood where I could be mugged and end up in the ER. Now I have a "walks through bad neighborhoods" surcharge? Where does it end?
Re:Compass Pathways has set itself up to be the first legal ... by waynecochran on Sunday January 06, 2019 @06:18PM (#18841389)
It is a matter of fairness. The way insurance traditionally worked is that your cost was proportional to your risk; This is what actuaries do for a living. Insurance companies live and die on actuarial tables. I was asked whether I smoked for my life insurance -- that was a fair question. Of course this will always be a crude estimate, but drug use voluntarily puts one in a higher risk category and actuaries can give you the numbers.

Now this should not be the end of the story. I understand there are folks who need medical treatment that can not afford it. There should always be a mechanism to make sure folks get the necessary help. I would hope the church or some other private entity would step up -- and often do. If not, then the final catch is the government.

The government taking over the whole health insurance industry is a naive solution that will result in crappy coverage for everyone. I don't claim to have a complete solution -- it is a difficult problem. I don't like extremes in either direction : completely privatized and completely government run are both bad solutions.

Re:Compass Pathways has set itself up to be the first legal ... by RankingMember on Monday January 07, 2019 @04:01PM (#18850013)
> The government taking over the whole health insurance industry is a naive solution that will result in crappy coverage for everyone.

This is demonstrably false when you consider the quality of coverage in places like France and Denmark.

I find the fairness argument understandable from a distance, but it falls apart when you look closer and realize the amount of overhead involved in managing such a system where we make sure everyone pays according to their risk profile, which itself, would be dependent on numerous subjective measures not to mention the potential for intentional or unintentional inaccurate reporting. As an example, our tax dollars go to pay for infrastructure whether we're driving on the roads and bridges they pay for or not, and we don't pay more or get refunds if we use more or less roads. Would it be fairer to only charge you for roads you use? Absolutely, but it'd also be a ton of overhead to administer.

Re:Compass Pathways has set itself up to be the first legal ... by daveFNbuck on Sunday January 06, 2019 @01:46AM (#18836971)
What if their employers decline to pay for it? Or what if people with dangerous hobbies decide to take the risk and not pay for additional insurance? Are you OK with these people dying because they can't afford to pay for their health care?
Re:Compass Pathways has set itself up to be the first legal ... by waynecochran on Sunday January 06, 2019 @06:24PM (#18841418)
Every now and then I hear of someone in a wing suit dying. I don't like hearing about anyone's death, but I realize they knew the risks. I am not sure where I stand on legalization of various drugs, but I do feel they should have a higher insurance rate. I'm am not OK with anyone dying, but my sympathy level does vary. In fact, I have a higher sympathy for folks who are hooked on various drugs and are trapped by their lifestyle. I am not above my own addictions.
Re:Compass Pathways has set itself up to be the first legal ... by elcomet on Friday January 04, 2019 @11:43AM (#18825374)
> No user of this product has ever harmed anyone else as a result of using it.

I definitely don't agree with this. You are harming your family and friends by harming yourself.

People can care about you.

Re:Compass Pathways has set itself up to be the first legal ... by perfmode on Friday January 04, 2019 @11:44AM (#18825386)
this isn’t an addictive substance.

Edit: the OP removed statement about addiction

Re:Compass Pathways has set itself up to be the first legal ... by elcomet on Friday January 04, 2019 @11:46AM (#18825407)
I removed the addictive part. This substance can have dangerous side-effects and bring you to the hospital, so it doesn't need to be addictive to hurt yourself.
Re:Compass Pathways has set itself up to be the first legal ... by RankingMember on Friday January 04, 2019 @12:22PM (#18825764)
> You are harming your family and friends by harming yourself.

What of drinking alcohol? Eating too much food? Riding a bike without a helmet? Taking an antidepressant with known potentially dangerous side effects? Going outside without a jumpsuit made out of Nerf foam? At what point do you get to live your life for yourself instead of avoiding doing things you think others might not want you to do?

Re:Compass Pathways has set itself up to be the first legal ... by elcomet on Friday January 04, 2019 @12:40PM (#18825929)
Of course. The point is that there is a scale of dangerousness. What are the odds of getting an accident riding a bike vs taking drugs like these ?

I think jumpsuits should be forbidden for the same reason, but that's just a personal opinion.

Re:Compass Pathways has set itself up to be the first legal ... by RankingMember on Friday January 04, 2019 @02:12PM (#18826786)
Surely, but I think your danger meter may need recalibration here. Dying of toxicity of psilocybin is practically unheard of (unlike with alcohol, for example), and while there are no solid stats on injury/death related to behavior while on this drug, it is considered the safest of recreational drugs according to a recent global drug survey: https://www.theguardian.com/society/2017/may/23/study-halluc...

Given the chances you'll be riding your bike among cars piloted by people on prescription painkillers or alcohol, I'd be surprised if riding a bike isn't significantly more dangerous than taking psilocybin, but once again, there are no good stats on psilocybin-related behavioral results so this is just speculation.

Re:Compass Pathways has set itself up to be the first legal ... by Matticus_Rex on Friday January 04, 2019 @05:09PM (#18828155)
What exactly are the dangerous side-effects of psilocybin? Yes, you shouldn't drive or make big decisions while on it, but that's not hard to control for (and is similar to many OTC medicines). What are the side-effects that are sending you to the hospital?
Re:Compass Pathways has set itself up to be the first legal ... by jMyles on Friday January 04, 2019 @01:53PM (#18826599)
> You are harming your family and friends by harming yourself.

Are you asserting that this is per se the outcome of ingesting psilocybin?

Re:Compass Pathways has set itself up to be the first legal ... by atomical on Friday January 04, 2019 @11:37AM (#18825304)
The blind spot here is that no one really understands how it works or the long term implications. It may have a use for patients with treatment resistant medical conditions where the alternatives have failed or side-effects are intolerable.

Why should healthy adults take this substance? Many of the so-called experts interviewed in Michel Pollan's new book took psilocybin and believed the experience revealed the inner truths of the universe. It seemns like it could be quite harmful for more people to embrace meta-magical thinking.

Related: 1) Michael Pollan is interviewed on a podcast by Tyler Cowen. They briefly talk about whether psychedelics have contributed to society through novel discoveries. 2) Robert Sapolsky's lectures and book Trouble with Testosterone touch on meta-magical thinking.

Re:Compass Pathways has set itself up to be the first legal ... by jschwartzi on Friday January 04, 2019 @12:49PM (#18826011)
I think it's disingenuous to argue from the stance that magical thinking is bad and should be prevented, and thus that the drug is bad and should be eliminated. I think you'd be surprised just how many functional people have magical beliefs and especially how many scientists and engineers do. The notion that a pattern of thought is dangerous and should be outlawed has probably done more harm to the world than "meta-magical thinking."
Re:Compass Pathways has set itself up to be the first legal ... by sjg007 on Friday January 04, 2019 @12:12PM (#18825664)
Well... I think the oneness effect is interesting where people basically feel interconnected. Kind of like astronauts who see the world from space. That feeling should be a positive one. It's also not clear it is permanent. It may impact your degree of openness.

What I've found interesting in his book is that the suggestions of the therapist lead basically influence the result. So if someone says what will happen on shrooms you basically have a similar experience. That is interesting.

Further along the meta magical thinking idea is the stoned ape hypothesis which basically tries to explain how we were able to transcend "primitiveness" and develop abstract reasoning and as such technological progress by using psychedelics. Whether there is evidence for this or not I don't know.. haven't read the stoned ape book.. It does seem more plausible that magic mushrooms led to religion. I've been reading Pollan's book as well and the part about AA 12 step and Bill's wanting to use magic mushrooms as part of the process is very interesting. Turns out that the board allegedly wanted to keep the straight religion aspect in it for control vs surrendering yourself to mushrooms. This is partly why psychedelics are being tested on reducing alcoholism.

If it can help alleviate depression and anxiety I am 100% behind it. So much time, energy and life is lost to that mindfuck of a state.

* also we don't really understand the long term implication o f a lot of things we eat or drink or the legal drugs we take. Should you eat eggs? margarine? wine? tea? how much coffee? etc..

Re:Compass Pathways has set itself up to be the first legal ... by achileas on Friday January 04, 2019 @03:42PM (#18827416)
While it's a fun hypothesis, there's no evidence for that (nor the bicameral mind hypothesis).
Re:Compass Pathways has set itself up to be the first legal ... by StrictDabbler on Friday January 04, 2019 @01:17PM (#18826270)
On Psilocybin:

Anecdotally, mushrooms are about as likely to disrupt existing patterns of magical thinking as they are to inspire new ones.

The experience of being absolutely certain that your friend in the other room can read your thoughts and the discovery when you come down that no, he was thinking something completely different than you thought is sobering.

The experience of realizing how large the world is, how many people are in it talking at all times, can undermine conspiracy theories that depend on a tiny cabal of people keeping a secret while using hundreds of workers to accomplish a task, like faking the moon landing.

The "inner truths of the universe" that people feel are exposed by mushrooms are so abstract that they're not likely to actually interfere with rational thought. Mushrooms induce a metaphoric mode of thought. Realistically, we are all connected, by atmosphere, ecosphere, society and economy.

It's true that we don't have a solid scientific understanding of the long term implications, but we have a pretty solid population of people who've done mushrooms casually. It's not an uncommon drug.

All that aside, we have an FDA review process so that we can evaluate the safety of a drug. No drug is ever evaluated to see if it has a long-term negative societal effect because of how it alters your world-view. The effects that Depakote, Prozac and Ambien have had on society are likely significant and are largely unknown.

On "metamagical thinking":

I just spent some significant time trying to find out what "metamagical thinking" is supposed to be.

Try it yourself. You'll find many people quoting Sapolsky thus: "It's the shamans who are moving separate from everyone else, living alone, who talk with the dead, who speak in tongues, who go out with the full moon and turn into a hyena overnight, and that sort of stuff. It's the shamans who have all this metamagical thinking." What you won't find is any kind of formal definition of metamagical processes or arguments for the term.

You'll find two places in his book "Biology and Human Behavior" but in each case it is only used as an adjective describing the symptoms of schizotypal personality disorder. In the DSM this is instead described as "magical thinking," no meta involved. In "Trouble with Testosterone" Sapolsky only refers to "magical thinking."

Sapolsky appears to have just added the "meta" as a sort of unthinking affectation for a period of time and to have dropped it later. I'd be interested in evidence to the contrary.

I say all this because Hofstadter invented the term "metamagical" to describe a certain kind of highly intellectual examination of the edges of analogy and meaning in rational systems and it's a hell of a phrase. It's a shame to have Sapolsky's non-use replicating across the internet.

Re:Compass Pathways has set itself up to be the first legal ... by nopacience on Friday January 04, 2019 @11:45AM (#18825398)
long term implications of a living human being is death. the live human being will create pollution, will kill a couple of ants, might become a murder, a liar. Life is risky.
Re:Compass Pathways has set itself up to be the first legal ... by Retra on Friday January 04, 2019 @11:49AM (#18825443)
It's unnecessarily more risky when you do stupid things. You can't use a little risk to justify arbitrarily more risk, you have to make an argument based on the value produced.
Re:Compass Pathways has set itself up to be the first legal ... by johnisgood on Friday January 04, 2019 @12:02PM (#18825570)
The substance of interest is psychedelics. According to what we know, they are pretty safe. Additionally, it is most definitely not "unnecessarily". Introspection, personal growth, and so on is not "unnecessary" to me and to many people. If it is to you, that is fine by me.

Not sure what you are referring to by "stupid things" though.

Re:Compass Pathways has set itself up to be the first legal ... by atomical on Friday January 04, 2019 @12:23PM (#18825771)
I think you're focusing on safe from an LD50 perspective? My comment addressed the question of significant changes to the mind.
Re:Compass Pathways has set itself up to be the first legal ... by Retra on Friday January 04, 2019 @12:14PM (#18825683)
I don't have any serious qualms with psychedelics. I have a problem with someone arguing that they should be legal solely on the basis that risk is acceptable. By that argument, I should like to wave a loaded gun in your face.

But that would be a stupid and unnecessary risk, so obviously there is more to the question of regulation than what risks people feel like they want to take.

Re:Compass Pathways has set itself up to be the first legal ... by Fricken on Friday January 04, 2019 @12:15PM (#18825693)
In theory humankind can persist indefinitely, so long as we don't fuck it up, but we are fucking it up, we're destroying the life support systems that sustain us. That's unacceptable risk.

Individuals on the other hand don't live forever, the risk of death is 100% for everyone, so individual risk isn't something we need to get uptight about.

Re:Compass Pathways has set itself up to be the first legal ... by nopacience on Friday January 04, 2019 @12:05PM (#18825600)
Lots of people have died in car accidents. Many people have died because of knifes. Many people have died because went to the wrong place where wild animals were hungry.

What is the solution in this case ? All the situations here are riskier.

Many people die after they wake up and leave their room. So its risky to leave their room.

You are not a genius.

Re:Compass Pathways has set itself up to be the first legal ... by Retra on Friday January 04, 2019 @12:15PM (#18825697)
I literally do not understand what you are responding to right now.