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A comment on The Link Between Inflammation and Depression?.

Re:The Link Between Inflammation and Depression? by Bucephalus355 on Monday December 24, 2018 @05:13PM (#18754568)
This is very important. It’s not yet fully understood, but something is missing yet in our understanding of inflammation.

It’s not everything, just like antibiotics weren’t everything, but progress here will mean curing an incredible amount of human suffering.

The book linked below, a late 2015 text on Molecular Neuropharmacology, is fascinating. Every chapter has a mention of inflammation and usually ibuprofen. It’s that important.

Particularly fascinating is the connection with ADHD, Parkinson’s, and Schizophrenia. All of the diseases have something to do with dysregulation of Dopamine. In particular, it seems like Ibuprofen helps with reducing the effects of Dopamine overload, which is essentially what Schizophrenia is. It’s an inflammation of the mind that is somewhat similar to how we now think sugar causes harm/inflammation. Anyway this overload eventually can lead to underload, or Parkinson’s. ADHD individuals are often overloaded as well due to the treatment with stimulant medication (which is good but can be abused).

I’m not kidding when I say there are Nobel prizes being left on the table here right now.

https://www.amazon.com/Molecular-Neuropharmacology-Foundatio...

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Re:The Link Between Inflammation and Depression? by auganov on Monday December 24, 2018 @05:46PM (#18754702)
Interesting definitely adding this to my reading list for self serving reasons. I independently came to similar ideas about inflammation, mostly because I have to take a lot of Ibuprofen for chronic pain and what works best is taking some preemptively on non painful days. That is, I always tried to think up more reasons for why this isn't a terrible idea.
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Re:The Link Between Inflammation and Depression? by 995533 on Monday December 24, 2018 @07:49PM (#18755152)
Ibuprofen may cause ulcers, bleeding, or holes in the stomach or intestine.
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Re:The Link Between Inflammation and Depression? by giardini on Tuesday December 25, 2018 @12:21AM (#18756060)
Always possible, but I've taken taking 200 mg ibuprofen 2X per day for 30 years w/o a problem. I also take an 81 mg aspirin every night. I take turmeric and cinnamon with my coffee in the morning. If I get a bad headache I take two 325-mg aspirin also.

I have no stomach problems unless I drink too much Starbucks coffee over a 3-day period.

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Re:The Link Between Inflammation and Depression? by natalyarostova on Tuesday December 25, 2018 @12:36PM (#18758232)
Why so much ibuprofen?
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Re:The Link Between Inflammation and Depression? by giardini on Wednesday December 26, 2018 @12:49AM (#18760823)
That's enough for me. The directions on the bottle recommend 1 x 200 mg pill every 4-6 hours. But it is possible to take a lot more: the max is 3200 mg/day. I've never had any stomach problems with ibuprofen or other NSAIDs.

I once cracked a rib and my doctor put me on 800 mg ibuprofen twice a day. _All_ pain went away as my swim times dropped steadily - so much so that it was upsetting the swim team's male hierarchy. Each new day I was recovered and invigorated, much to the irritation of my teammates. This went on for a month until the prescription expired. My swim times rose over the next 3 days as swimming became harder and the usual day-to-day pains returned.

Some people say that NSAIDs will prevent you from improving your ability in athletic events but that was not true for me and ibuprofen.

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Re:The Link Between Inflammation and Depression? by auganov on Tuesday December 25, 2018 @01:27PM (#18758562)
This is very little actually, this is what I take on non-painful days. When it hurts it's 800mg every 4-6 hours (up to 3200mg daily) combined with either 500mg or 1g acetaminophen depending on severity. Usually 1 or two rounds are enough, but definitely hit the limit a few times. These are pretty common dosages for anybody with serious pain.

Around 3 years on that regimen so far.

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Re:The Link Between Inflammation and Depression? by wolco on Monday December 24, 2018 @09:55PM (#18755578)
tumeric might be more powerful.
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Re:The Link Between Inflammation and Depression? by meowface on Tuesday December 25, 2018 @11:35AM (#18757957)
Curcumin/theracurmin yes, turmetic no.
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Re:The Link Between Inflammation and Depression? by thatoneuser on Tuesday December 25, 2018 @03:28PM (#18759076)
It’s incredible. This last year this very link has become glaringly obvious to me. When depression kicks into overdrive inflammation seems to be right there with it. I’ve had some somewhat chronic issues and I’m really not sure if I should approach it in a physical sense (pt, excercise, etc) or if I should be doing more mental work.

Can’t wait for the science to mature a bit here for better direction. Pain killers (ibuprofen and others) scare the hell out of me now more than ever because they seem like an easy way out (read: temporary solution). And that’s a dark, dark path to tread on.

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Re:The Link Between Inflammation and Depression? by DoreenMichele on Tuesday December 25, 2018 @03:36PM (#18759106)
Ibuprofen therapy is a common treatment for the inflammation in my condition. Dietary changes helped me eventually get off daily ibuprofen. I was on it about six years.
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Re:The Link Between Inflammation and Depression? by DoreenMichele on Tuesday December 25, 2018 @03:35PM (#18759097)
It’s not yet fully understood, but something is missing yet in our understanding of inflammation.

Inflammation can have chemical roots. It can also be a side effect of infection.

It seems to me that this is why it's so complicated. Correlation does not prove causation. In order to treat conditions associated with inflammation, wecmay need to identify and resolve the things causing the inflammation.

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Re:The Link Between Inflammation and Depression? by starbeast on Monday December 24, 2018 @10:52PM (#18755789)
Was having a similar discussion about this subject with my brother today, I completely agree on the importance. The shift from it being all in the head to recognizing that in many cases there is a physical and treatable illness going on will be a revolution. And not an easy one either.
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