I admit to not taking emotions into consideration here.
When you're multiplying large numbers you only need around 5 or 6 items.
His talent was mainly that he could factor super quickly, and had the times tables memorized up to some absurd level. So that just cut a lot of thinking out of the task.
I am unsure about chunking for random large numbers though. Mnemonic champions chunk very large numbers (I don't have sources on hand), but normal people generally don't.
The original multiplicands are honestly the hardest to remember. Don't materialize all of the intermediate results, and you can stay within working memory. You'll need to chunk a little, but mostly only 2 digit numbers.
Personally, I use fingers to keep track of the 10s place, and work from left to right. Less overwriting that way, and you start with an underapproximation that you refine gradually, which means you can stop early when estimating.
As in e.g. 365 * 128? Or 365 * 8? The latter is realistic, the former is a bit unbelievable. Even the latter is a violation of the "magic 7"[0].
[0]https://en.wikipedia.org/wiki/The_Magical_Number_Seven,_Plus...