I haven't done .Net for a couple years but Microsoft never really supported F#. It wasn't a full-fledged citizen in their web frameworks; you could include compiled modules that you made with F# but couldn't use it the way you use VB or C#. And you'd think a functional language would be great for data transformations in SSIS, but same deal there, just VB or C#.

Microsoft always positioned it as "use F# for the hard stuff and C# for the rest." The trouble is that C# isn't that bad for the hard stuff, and if you're spending most of your time with C#, then for you it's probably better than F#.