Ask many genuine scientists who have been doing research in a field for 30+ years and they can tell you how small the book knowledge is compared to the unexplored territory.
We're also taught by "genuine" scientist, people with PhDs, PhD/MD, and MDs on a daily basis about what we don't know.
I really appreciate this being taught, and from what little you wrote, I appreciate the humility shown. Please don't ever become a "big shot" that's too good to talk openly to people who are afraid about their health.
And you have a warped view of what Doctors are. They are not Research Scientists. They are not there to try out cutting edge techniques and medicines. They are not there to be the world's foremost knowledge on everything medical.
They are there to give you conservative, boring advice vetted by the authorities for specific ailments. Anything more serious they recommend you to see specialists.
You know this since you have a medical degree, but to inform general readers, here's what takes to become a doctor in the USA[1]:
After all that, they probably do think they know it all. But in reality their knowledge has only scratched the surface.Perhaps the right answer is even more specialization? Maybe that's where places like the Mayo Clinic come in? Maybe an organization like that is big enough that they can have specialists who can recognize and treat all the rare conditions that are "not in the book"?
[1] https://en.wikipedia.org/wiki/Medical_school#United_States