I would believe that. I paid for a kit, never got a confirmation. Waited a few months and finally contacted customer service. They said it would be shipped soon. It never was. I cancelled the order, asked for (and got) a refund. No follow up, nothing. Not even a GDPR email during the wave of them earlier this year, something I would expect from such a business. I don’t know, maybe I’m paranoid after reading Bad Blood but something ain’t right. Their marketing machine still churns though. From time to time I still see ads.

Given the health and medical play, I think they're questionable in at least a couple of ways.

- There are no actions to be taken based on microbiome data

- There's no government oversight to the quality of their sequencing or bioinformatics

- The reviews don't indicate the kits are useful https://www.highya.com/ubiome-reviews

Maybe a good comparison would be if Theranos gave you a 'subjective wellness score' instead of standard test results

You summed up my concerns better than I could.

I remember when uBiome launched out of UCSF. I remember thinking “ok, they’ll sequence your microbiome and then...what exactly?”

I gave my data files from uBiome to a microbiologist and was told 'these data are too low in quality to analyze'

Yikes.

To be honest, the microbiome space is interesting and may hold promise for therapeutics - and maybe uBiome will be a leader in it.

But there is a very good chance that nothing will come of this whatsoever.

a fantasy: I get intestinal distress from food/water while on vacation. I take antibiotics to clear the problem. At a later date, I have a fecal transplant [0]. It couldn't be mine, because that was the site of the problem. Instead, I order a culture that matches my previous microbiome distribution.

[0] https://arstechnica.com/science/2018/09/probiotics-if-you-do...

I think to do this, you'd need data points that don't yet exist: if your microbiome changes from antibiotic use, will you suffer health effects (beyond infection with a disease causing bacteria like C. difficle)?

My wife and I both got kits (reasonably quickly shipped) and got our results, also reasonably quickly (within a few weeks of sending them back if I recall). But the results were almost identical between us, even though we have very different digestive health systems/symptoms. There was one metric that was totally out of normal range, but the reading was exactly the same between the two of us. We were definitely left not being able to get any useful information out of the data and not trusting it at all. I think my wife emailed them asking why the results were basically identical to mine (including the totally abnormal metric), and I don't think she ever got a reply.

I'd be far more surprised if you and your wife had markedly different microbiomes.

> I think my wife emailed them asking why the results were basically identical to mine (including the totally abnormal metric), and I don't think she ever got a reply.

Well, to be fair, one of the working hypotheses about human mating behavior is that one of its goals is to equalize the biome of the female (bacteria, viruses, etc.) to that of her partner before she gets pregnant.

So, husband and wife having the same biome is not surprising.

And, even if you have the same biome, your systems will almost certainly react differently depending upon the expressed receptors.

Totally fair, but then what use is the data? If we have totally different digestive reactions / problems, then can you really tell much of anything from the microbiome data?

> If we have totally different digestive reactions / problems, then can you really tell much of anything from the microbiome data?

Congratulations. You now understand why the folks trying to monetize microbiome are regarded as snake oil salesmen right now.

I'm sure there are broad strokes that are valid. You have a lot of bacterium X--that isn't good. You completely lack bacterium Y--that isn't good. Your overall diversity is low--you probably should try to correct that.

However, once you start getting into "you need specific bacterium X to solve specific problem Y", that's likely snake oil.

Biological systems are annoying like that. For any treatment X, there will be some, generally tiny, fraction of the population that responds to it.

The problem is finding a treatment that works in either 1) the vast majority of the population or 2) a readily identifiable minority of the population.

Microbiome work is probably going to produce some cool results, but it will take time to get there. Running experiments on people is time consuming and expensive.

Please don't do this here.

It’s not unusual in the slightest for people living together to have very similar microbiomes even in the absence of direct contact like that.

I always pose the question - your gut was sterile when you were born, so how do you think the bacteria got their in the first place? The answer is oral-fecal transmission.

You get fecal bacteria on your hands, you touch an object, someone else touches it and they put their hands in their mouth.

You must be one of the guys I team up with sometimes on playstation. (tbh it's a fair question in this context)

Yep. They still owe me the $80 or $90 I paid for a kit. I followed up with them multiple times and never got a resolution. This was a couple of years ago.

Why didn't you just file a chargeback?

Hi there! Please email us at [email protected] and we'd be happy to look into this.

I did. Multiple times. I do not want to relive the experience of trying to get my money back. I also don't want to support the growing tendencies of companies to not care about customer complaints until they hit social media.

Grapevine is true. What they are doing is extremely questionable. They are billing insurance thousands of dollars for tests that are rudimentary and only look at absence or presence of microbes.

Look at Better Business Bureau and Customer Reviews, https://www.bbb.org/us/ca/san-francisco/profile/clinic/ubiom... https://www.highya.com/ubiome-reviews