High fat consumption raises inflammatory profiles through mechanisms that are poorly understood. Carbohydrates seem to cause similar inflammation, but this is largely do to advanced gylcation end-products created from fructose, specifically.
Overeating is not interesting. The reason people do overeat is very interesting, and if you hit the literature you find that this is largely driven by damage to the hypothalamus by environmental exposure.
What if it's not. What if people just overeat because life is boring, and food tastes good, and we all have differing levels of willpower & education on nutrition?
> if you hit the literature you find that this is largely driven by damage to the hypothalamus by environmental exposure.
Sounds like nonsense, can you elaborate?
Then we need to explain why this suddenly became a problem in the 1970s. Life is more boring now? We all lost our willpower? People understood nutrition better before that? Something has changed, either in humanity or the environment. My bet is the environment.
Since theres no blood brain barrier here, these neurons get damaged easily due to things in the blood. When that happens, they don't see leptin anymore, and obesity develops. Fructose and high fat diets have both been shown to cause inflammation here. (hypothalamic gliosis)
heres a random selection of many papers http://diabetes.diabetesjournals.org/content/65/3/551.figure...
We also know that certain viruses show up in obese people (adenovirus36). As the field develops, I would not be surprised if labs demonstrate both viral infection of the hypothalamic ARC and damage by endocrine disruptors there.
People reach obesity from overeating, no matter what their choice of calorie-dense foods, but it's typically sugar or fats, and sugar is the cheapest/most available.
Being obese is clearly a causative factor towards T2B [1]. How are these obvious truths 'running on a treadmill'?
[1] https://www.diabetes.co.uk/diabetes-and-obesity.html